Recombinant Human AICDA, His-tagged

• Cat.No.: AICDA-7113H
• Product Overview: Recombinant human AICDA protein, fused to His-tag at N-terminus, was expressed in E.coli.

Specification

• Description: AICDA, also known as AID, is involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. This protein is required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. It may also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
• Molecular Mass: 26.1kDa (218aa)
• Protein length: 1-198aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MDSLLMNRRK FLYQFKNVRW AKGRRETYLC YVVKRRDSAT SFSLDFGYLR NKNGCHVELL FLRYISDWDL DPGRCYRVTW FTSWSPCYDC ARHVADFLRG NPNLSLRIFT ARLYFCEDRK AEPEGLRRLH RAGVQIAIMT FKDYFYCWNT FVENHERTFK AWEGLHENSV RLSRQLRRIL LPLYEVDDLR DAFRTLGL
• Purity: >85% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml

Gene Information

• Gene Name: AICDA activation-induced cytidine deaminase [ Homo sapiens ]
• Official Symbol: AICDA
• Synonyms: AICDA; activation-induced cytidine deaminase; AID; ARP2; CDA2; HIGM2; cytidine aminohydrolase; integrated into Burkitts lymphoma cell line Ramos
• Gene ID: 57379
• mRNA Refseq: NM_020661
• Protein Refseq: NP_065712
• MIM: 605257
• UniProt ID: Q9GZX7
• Chromosome Location: 12p13
• Pathway: IL4-mediated signaling events, organism-specific biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem; Primary immunodeficiency, organism-specific biosystem; Primary immunodeficiency, conserved biosystem; salvage pathways of pyrimidine deoxyribonucleotides, organism-specific biosystem; salvage pathways of pyrimidine ribonucleotides, organism-specific biosystem
• Function: cytidine deaminase activity; cytidine deaminase activity; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; metal ion binding; protein binding; zinc ion binding