Recombinant Human AICDA, His-tagged

• Cat.No.: AICDA-9502H
• Product Overview: Recombinant Human AICDA protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2).
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 1-198a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: AICDA activation-induced cytidine deaminase [ Homo sapiens ]
• Official Symbol: AICDA
• Synonyms: AICDA; activation-induced cytidine deaminase; AID; ARP2; CDA2; HIGM2; cytidine aminohydrolase; integrated into Burkitts lymphoma cell line Ramos
• Gene ID: 57379
• mRNA Refseq: NM_020661
• Protein Refseq: NP_065712
• MIM: 605257
• UniProt ID: Q9GZX7
• Chromosome Location: 12p13
• Pathway: IL4-mediated signaling events, organism-specific biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem; Primary immunodeficiency, organism-specific biosystem; Primary immunodeficiency, conserved biosystem; salvage pathways of pyrimidine deoxyribonucleotides, organism-specific biosystem; salvage pathways of pyrimidine ribonucleotides, organism-specific biosystem
• Function: cytidine deaminase activity; cytidine deaminase activity; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; metal ion binding; protein binding; zinc ion binding