Recombinant Human Activin-B

• Cat.No.: Activin-B-3122H
• Product Overview: Activin-B

Specification

• Species: Human
• Source: Nicotiana Benthamiana
• Tag: Non
• Protein Length: 407
• Description: The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
• Form: Lyophilized
• Molecular Mass: 45,122 Da
• Purity: >97% by SDS-PAGE gel
• Notes: Small volumes of Activin-B recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: This lyophilized preparation is stable at 2-8 degree C for short term, long storage it should be kept at -20 degree C. Reconstituted protein should be stored in working aliquots at -20 degree C and it is recommended to add a carrier protein (0.1% HSA or BSA). Repeated freezing and thawing is not recommended.
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: INHBB inhibin, beta B [ Homo sapiens ]
• Official Symbol: INHBB
• Synonyms: INHBB; inhibin beta B chain; Inhibin, beta-2; activin beta-B chain; activin AB beta polypeptide
• Gene ID: 3625
• mRNA Refseq: NM_002193
• Protein Refseq: NP_002184
• MIM: 147390
• UniProt ID: P09529
• Chromosome Location: 2cen-q13
• Pathway: AGE/RAGE pathway, organism-specific biosystem; Antagonism of Activin by Follistatin, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem
• Function: cytokine activity; growth factor activity; hormone activity