INHBB
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Official Full Name
inhibin, beta B -
Overview
Type I Diabetes is mainly characterised by limited or fully missing secretion of the hormone insulin. Morphological studies demonstrated a destruction of the beta cells of the so-called Langerhans cells (islet cells) in type I diabetics. Numerous researchers described the appearance of antibodies directed against the islet cells and insulin as the causal reason for the onset of the disease.<br/>Anti-Insulin antibodies are found in 37 percent of patients with newly detected Type I Diabetes, in 4 percent of their relatives of the first degree and in up to 1.5 percent of healthy controls. A positive correlation between the appearance of anti-Insulin and anti-islet cell antibodies has been reported. Anti-Insulin autoantibodies may be detected several months and in some cases years before the onset of the fully clinical manifestation of the diseases. Occasionally also autoantibodies to Pro-Insulin may appear.<br/>These ''true'' anti-Insulin autoantibodies directed against endogenous insulin have to be distinguished from those autoantibodies which are developed in insulin dependent diabetics undergoing therapy with insulin preparations of animal origin. In fact the latter have to be referred to side effects. These side effects may occur as local reactions of the skin by development of insulin-specific autoantibodies. These autoantibodies are causing the formation of an insulin depot and they may simulate a resistance against the hormonal treatment with animal insulin. Additionally other immunological phenomenon have been reported for Type I diabetics. A lot of other autoantibody specificities have been detected in those patients, too, but these antibodies must not cause additional autoimmune phenomenon. -
Synonyms
INHBB;inhibin, beta B;inhibin, beta B (activin AB beta polypeptide);inhibin beta B chain;Inhibin, beta-2;activin beta-B chain;activin AB beta polypeptide;MGC157939
Recombinant Proteins
- Human
- Chicken
- Mouse
- Pig
- Rat
- Zebrafish
- HEK293
- Nicotiana Benthamiana
- Hi-5 Insect Cells
- E.coli
- Insect Cells
- Mammalian Cells
- Human Cells
- CHO
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- GST&His
- Avi&Fc&His
- GST
Involved Pathway
INHBB involved in several pathways and played different roles in them. We selected most pathways INHBB participated on our site, such as Cytokine-cytokine receptor interaction,TGF-beta signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with INHBB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | PCGF2,ID1,FGFR3,PAX6,WNT3,WNT7A,WNT4,ESX1,PIK3CG,FGFR4 |
| TGF-beta signaling pathway | GDF6,ID4,RPS6KB2,ROCK1,CUL1,GDF6A,BMP2,CHRD,RPS6KB1,TGFB1A |
| Cytokine-cytokine receptor interaction | TGFBR2,GM13305,CXCL12,Kitl,IFNA17,GM13306,LEPR,TGFBR1A,VEGFAA,CXCL16 |
Protein Function
INHBB has several biochemical functions, for example, cytokine activity,growth factor activity,hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INHBB itself. We selected most functions INHBB had, and list some proteins which have the same functions with INHBB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transforming growth factor beta receptor binding | GDF10,INHBA,BMP15,INHBC,GDF15,GDF10B,BMP3,SPAW,NDR2,LEFTY2 |
| protein binding | SOCS1,NAT8,MXD3,INTS9,FLT1,P2RY1,DDX11,RSAD2,PRKAA2,ZCCHC13 |
| protein homodimerization activity | ATIC,NFKB1,GPD1A,BHLHA15,FGFR1,CTBP2A,DLK2,PLCB1,PVALB,CUL3 |
| hormone activity | GCG,PRL8A8,NPPB,FNDC5,INSL5,ADM2,LEPA,SMTLA,Retnla,ADCYAP1A |
| cytokine activity | HMGB1,IFNT2,TGFB2,CSF1,CMTM2B,TNF,CER1,IL36B,TXLNA,IFNG1-2 |
| growth factor activity | IL6,GSDF,HDGF,VEGFB,BMP1,AREG,FGF13B,CLEC11A,CECR1,TDGF1 |
Interacting Protein
INHBB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INHBB here. Most of them are supplied by our site. Hope this information will be useful for your research of INHBB.
ACVR1C;FNTA
Resources
Research Area
Early Mesodermal Lineage MarkersEctodermal Lineage Markers
Mesodermal Lineage Markers
Activins
Activins / Inhibins
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References
