Recombinant Human AATF, GST-tagged

• Cat.No.: AATF-9201H
• Product Overview: Recombinant human AATF protein, fused to GST-tag, was expressed in E.coli and purified by GST-sepharose.

Specification

• Description: The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 7-212a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: AATF apoptosis antagonizing transcription factor [ Homo sapiens ]
• Official Symbol: AATF
• Synonyms: AATF; apoptosis antagonizing transcription factor; protein AATF; CHE 1; CHE1; DED; rb-binding protein Che-1; apoptosis-antagonizing transcription factor; CHE-1
• Gene ID: 26574
• mRNA Refseq: NM_012138
• Protein Refseq: NP_036270
• MIM: 608463
• UniProt ID: Q9NY61
• Chromosome Location: 17q12
• Pathway: Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; NRAGE signals death through JNK, organism-specific biosystem; Regulation of retinoblastoma protein, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signalling by NGF, organism-specific biosystem; p75 NTR receptor-mediated signalling, organism-specific biosystem
• Function: leucine zipper domain binding; protein binding; protein domain specific binding; sequence-specific DNA binding transcription factor activity; tau protein binding