AATF
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Official Full Name
apoptosis antagonizing transcription factor -
Overview
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. -
Synonyms
AATF;apoptosis antagonizing transcription factor;protein AATF;CHE 1;CHE1;DED;rb-binding protein Che-1;apoptosis-antagonizing transcription factor;CHE-1
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- Rat
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cell
- Sf9 Insect Cell
- HEK293
- In Vitro Cell Free System
- GST
- His
- His&T7
- Flag
- His&GST
- Non
- His&Fc&Avi
Involved Pathway
AATF involved in several pathways and played different roles in them. We selected most pathways AATF participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE,NRAGE signals death through JNK,Regulation of retinoblastoma protein, which may be useful for your reference. Also, other proteins which involved in the same pathway with AATF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of retinoblastoma protein | MYOD1,CKM,SMARCB1,ELF1,CBX4,BGLAP,ATF7,GSC,BRD2 |
| Signalling by NGF | DNAL4A,KIDINS220B,PRDM4,RTN4A,LINGO1B,DNAL4B,PCSK5,RIT1,LINGO1,DNAL4 |
| Cell death signalling via NRAGE, NRIF and NADE | ABR,KALRN,TIAM2,ARHGEF16,NET1,KALRNB,ARHGEF18A,FGD4A,OBSCN,FGD4 |
| NRAGE signals death through JNK | ARHGEF1A,MCF2L,ARHGEF18,FGD4,NET1,ARHGEF18A,DCLRE1B,FGD2,FGD4A,AKAP13 |
| Signal Transduction | PENK,PTPRU,LRP12,CRABP1B,OR7D2,OR52J3,METAP2A,GPR55A,STARD8,CCL19A.2 |
| p75 NTR receptor-mediated signalling | ARHGEF1B,LINGO1,PRDM4,LINGO1B,RTN4,RTN4A,OMG |
Protein Function
AATF has several biochemical functions, for example, leucine zipper domain binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AATF itself. We selected most functions AATF had, and list some proteins which have the same functions with AATF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | SCML2,ATF7A,STAT2,BLF,POU3F3A,ZHX3,BRD8,NR1D4B,GTF3A,CEBP1 |
| tau protein binding | SNCA,APOE,HDAC6,S100B,PPP2R2A,FKBP4,BIN1,DYRK1A,SERPINB1A |
| leucine zipper domain binding | ERC1,DDIT3,PMF1,MKL1,DAPK3,PAWR,NRL,CRX,KCNA3,ATF4 |
| poly(A) RNA binding | COA6,HSPA9,DARS,Api5,MRPS21,NXF1,SRSF10,DUSP11,STAU1,HIST1H4B |
| protein binding | KRTAP19-5,MAPK10,CASP7,EIF3J,MAP3K9,BCL2A1,BTC,SOST,WRNIP1,PDGFRB |
Interacting Protein
AATF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AATF here. Most of them are supplied by our site. Hope this information will be useful for your research of AATF.
CHEK2;NGDN;SP1;ATM;MAPT;RELA;POLR2J;Myl12a
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References
- Rodriguez, DA; Zamorano, S; et al. BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1 alpha. EMBO JOURNAL 31:2322-2335(2012).
- Lai, YJ; Lin, VTG; et al. The Adaptor Protein TRIP6 Antagonizes Fas-Induced Apoptosis but Promotes Its Effect on Cell Migration. MOLECULAR AND CELLULAR BIOLOGY 30:5582-5596(2010).
