Recombinant Full Length Human VHL Protein, N-His-tagged

• Cat.No.: VHL-336HFL
• Product Overview: Recombinant Full Length Human VHL Protein, fused to His-tag at N-terminus, was expressed in E. coli.

Specification

• Description: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
• Molecular Mass: 24 kDa
• AA Sequence: A DNA sequence encoding human full-length VHL.
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Pathways in cancer, Renal cell carcinoma, Ubiquitin mediated proteolysis
• Full Length: Full L.

Gene Information

• Gene Name: VHL von Hippel-Lindau tumor suppressor [ Homo sapiens (human) ]
• Official Symbol: VHL
• Synonyms: RCA1; VHL1; pVHL; HRCA1
• Gene ID: 7428
• mRNA Refseq: NM_000551.4
• Protein Refseq: NP_000542.1
• MIM: 608537
• UniProt ID: P40337