VHL
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Official Full Name
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase -
Overview
The Von Hippel-Lindau (VHL) protein is a substrate recognition component of an E3 ubiquitin ligase complex containing elongin BC (TCEB1 and TCEB2), cullin 1 (CUL1), and RING-box protein 1 (RBX1) . VHL protein has been shown to exist as three distinct isof -
Synonyms
VHL;von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase;von Hippel Lindau syndrome , von Hippel Lindau tumor suppressor;von Hippel-Lindau disease tumor suppressor;VHL1;protein G7;elongin binding protein;RCA1;pVHL;HRCA1
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- Human cells
- HEK293T
- His
- Non
- His&Fc&Avi
- His&T7
- His&Avi
- Flag
- N-MBP&C-His-Avi
- Myc&DDK
Involved Pathway
VHL involved in several pathways and played different roles in them. We selected most pathways VHL participated on our site, such as HIF- signaling pathway,Ubiquitin mediated proteolysis,Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with VHL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathways in cancer | SUFU,HSP90AB1,F2R,RAD51,HRAS,Ar,FN1,MSH6,BRCA2,PDGFRA |
| HIF- signaling pathway | PIK3CB,PDHA2,MAP2K2,BCL2,EIF4E1B,EP300,PFKL,PIK3R3,TCEB2,PIK3CG |
| Ubiquitin mediated proteolysis | SIAH1A,UBE2KA,HERC4,UBE2IB,FZR1A,UBE2O,PIAS4B,UBA6,PIAS2,RNF7 |
| Renal cell carcinoma | EGLN1,RAC1,BRAF,TCEB2,GRB2,ARNT,PAK3,RAP1B,RAF1,PIK3R1 |
Protein Function
VHL has several biochemical functions, for example, chemoattractant activity,growth factor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VHL itself. We selected most functions VHL had, and list some proteins which have the same functions with VHL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth factor activity | THBS4,CD320,IL6,INHBAA,FIGF,MDKB,FGF12B,PPBP,ENDOU,HDGF |
| vascular endothelial growth factor receptor 3 binding | FIGF,VEGFC |
| chemoattractant activity | HMGB2,HMGB1,FIGF,FGF8,FGF7,VEGFC,LGALS3,CCL15,CXCL12,CXCL12B |
| protein binding | CABP1,CALM1,S100A7,ATP2B4,RNF11,HSP90AB1,TSPYL4,DIXDC1,COX5A,NAT10 |
Interacting Protein
VHL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VHL here. Most of them are supplied by our site. Hope this information will be useful for your research of VHL.
HIF1A
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