Recombinant Full Length Human UGT1A3 Protein

Description :	This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene.
Source :	In Vitro Cell Free System
Species :	Human
Form :	Liquid
Molecular Mass :	58.8 kDa
Protein length :	534 amino acids
AA Sequence :	MATGLQVPLP WLATGLLLLL SVQPWAESGK VLVVPIDGSH WLSMREVLRE LHARGHQAVV LTPEVNMHIK EENFFTLTTY AISWTQDEFD RHVLGHTQLY FETEHFLKKF FRSMAMLNNM SLVYHRSCVE LLHNEALIRH LNATSFDVVL TDPVNLCAAV LAKYLSIPTV FFLRNIPCDL DFKGTQCPNP SSYIPRLLTT NSDHMTFMQR VKNMLYPLAL SYICHAFSAP YASLASELFQ REVSVVDILS HASVWLFRGD FVMDYPRPIM PNMVFIGGIN CANRKPLSQE FEAYINASGE HGIVVFSLGS MVSEIPEKKA MAIADALGKI PQTVLWRYTG TRPSNLANNT ILVKWLPQND LLGHPMTRAF ITHAGSHGVY ESICNGVPMV MMPLFGDQMD NAKRMETKGA GVTLNVLEMT SEDLENALKA VINDKSYKEN IMRLSSLHKD RPVEPLDLAV FWVEFVMRHK GAPHLRPAAH DLTWYQYHSL DVIGFLLAVV LTVAFITFKC CAYGYRKCLG KKGRVKKAHK SKTH
Applications :	Antibody Production; Functional Study; Compound Screening
Storage :	Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer :	50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Name	UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 [ Homo sapiens (human) ]
Official Symbol	UGT1A3
Synonyms	UDP glucuronosyltransferase 1 family, polypeptide A3; UDPGT 1-3; UGT1C; EC 2.4.1.17; UDP glycosyltransferase 1 family, polypeptide A3; OTTHUMP00000065199; UGT-1C; UDPGT; UGT1*3; UDP glucuronosyltransferase 1A3; UGT1-03; UDP-glucuronosyltransferase 1-3; UGT1.3; GNT1; UDP-glucuronosyltransferase 1-C; UGT1; UDP-glucuronosyltransferase 1A3; OTTHUMP00000065193
Gene ID	54659
mRNA Refseq	NM_019093
Protein Refseq	NP_061966
MIM	606428
UniProt ID	Q5DT01