Recombinant Full Length Human Ubiquitin-conjugating Enzyme E2L 3/UBE2L3 Protein

• Cat.No.: UBE2L3-33H
• Product Overview: Recombinant Human UbcH7(154amino acid) was over-expressed inE.coliand purified by using conventional chromatography techniques. MW = 17.9 kDa (154 aa).

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 1-154 a.a.
• Description: Human Ubquitin-conjugating enzyme 7(UbcH7) is a ubiquitin-conjugating enzyme (E2) mediating c-fos degradation, transcription factor NF-B maturation, and human papilloma virus-mediated p53 and Myc protein degradation, in vitro. The ubiquitin-conjugating enzymes(E2s) are essential components of the post-translational protein ubiquitination pathway, mediating the transfer of activated ubiquitin to substrate proteins. The human UBE2L1-UBE2L4 gene could potentially encode different isoforms of the UbcH7. UBE2L3 gene, located at chromosome 22q11.2, is the only identical family member with introns and encodes a polypeptide sequence identical to that of UbcH7.
• Amino Acid Sequence: MAASRRLMKE LEEIRKCGMK NFRNIQVDEA NLLTWQGLIV PDNPPYDKGA FRIEINFPAE YPFKPPKITF KTKIYHPNID EKGQVCLPVI SAENWKPATK TDQVIQSLIA LVNDPQPEHP LRADLAEEYS KDRKKFCKNA EEFTKKYGEK RPVD
• Form: Liquid. In 50 mM HEPES (pH 7.5) containing 150 mM NaCl 1 mM DTT and 10% glycerol.
• Purity: > 95% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: UBE2L3 ubiquitin-conjugating enzyme E2L 3 [ Homo sapiens ]
• Synonyms: E2-F1; L-UBC; UBCH7; UbcM4; ubiquitin-conjugating enzyme E2L 3; UB2L3_HUMAN; EC 6.3.2.19; Ubiquitin-protein ligase L3;Ubiquitin carrier protein L3; UBCE7; ubiquitin carrier protein; ubiquitin-conjugating enzyme E2L3; ubiquitin-conjugating enzyme UBCH7; ubiquitin-protein ligase; UBE2L3
• Gene ID: 7332
• mRNA Refseq: NM_003347
• Protein Refseq: NP_003338
• MIM: 603721
• UniProt ID: P68036
• Chromosome Location: 22q11.21
• Pathway: Parkinson"s disease
• Function: enzyme binding; ligase activity; small conjugating protein ligase activity; ubiquitin-protein ligase activity