Recombinant Full Length Human SNRNP70 Protein, C-Flag-tagged

• Cat.No.: SNRNP70-1189HFL
• Product Overview: Recombinant Full Length Human SNRNP70 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Enables U1 snRNA binding activity. Involved in mRNA splicing, via spliceosome and regulation of RNA splicing. Located in nucleoplasm. Part of U1 snRNP and spliceosomal complex. Implicated in disease of mental health and systemic lupus erythematosus. Biomarker of Alzheimer's disease.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 51.4 kDa
• AA Sequence: MTQFLPPNLLALFAPRDPIPYLPPL EKLPHEKHHNQPYCGIAPYIREFED PRDAPPPTRAETREERMERK RREKIERRQQEVETELKMWDPHNDP NAQGDAFKTLFVARVNYDTTESKLR REFEVYGPIKRIHMVYSKRS GKPRGYAFIEYEHERDMHSAYKHAD GKKIDGRRVLVDVERGRTVKGWRPR RLGGGLGGTRRGGADVNIRH SGRDDTSRYDERPGPSPLPHRDRDR DRERERRERSRERDKERERRRSRSR DRRRRSRSRDKEERRRSRER SKDKDRDRKRRSSRSRERARRERER KEELRGGGGDMAEPSEAGDAPPDDG PPGELGPDGPDGPEEKGRDR DRERRRSHRSERERRRDRDRDRDRD REHKRGERGSERGRDEARGGGGGQD NGLEGLGNDSRDMYMESEGG
  DGYLAPENGYLMEAAPETRTRPLEQ KLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Spliceosome

Gene Information

• Gene Name: SNRNP70 small nuclear ribonucleoprotein U1 subunit 70 [ Homo sapiens (human) ]
• Official Symbol: SNRNP70
• Synonyms: RPU1; Snp1; U1AP; U170K; U1RNP; RNPU1Z; SNRP70; U1-70K
• Gene ID: 6625
• mRNA Refseq: NM_003089.6
• Protein Refseq: NP_003080.2
• MIM: 180740
• UniProt ID: P08621

Reviews

02/06/2022

This may include providing detailed protocols, troubleshooting advice, and suggestions for experimental design.

04/27/2019

The manufacturer can provide researchers with high-quality ARMC6 protein, ensuring it is properly purified, characterized, and quality-controlled.

12/17/2018

This collaboration may extend beyond the purchase of the SNRNP70 protein, potentially leading to additional support, joint research projects, or access to expertise in the field.

Q&As

How is SNRNP70 linked to autoimmune diseases?

Autoantibodies against SNRNP70 are frequently found in individuals with autoimmune diseases, serving as a diagnostic marker for conditions like SLE.

Are there specific techniques used to detect anti-SNRNP70 antibodies?

Common methods include immunoprecipitation, enzyme-linked immunosorbent assay (ELISA), and Western blotting.

Can changes in SNRNP70 levels be used to monitor treatment response in autoimmune diseases?

Monitoring anti-SNRNP70 antibody levels during treatment may offer insights into the effectiveness of therapeutic interventions in autoimmune diseases.

How might SNRNP70 be a potential therapeutic target?

Understanding the role of SNRNP70 in autoimmune diseases could lead to the development of targeted therapies aimed at modulating its activity.

Can anti-SNRNP70 antibodies be found in diseases other than SLE?

Yes, anti-SNRNP70 antibodies are also associated with other autoimmune diseases such as mixed connective tissue disease (MCTD) and rheumatoid arthritis.