Recombinant Full Length Human RELB, His-tagged

• Cat.No.: RELB-1487H
• Product Overview: Recombinant full-length human Rel B was expressed by baculovirus inSf9insect cells using an N-terminal His tag. MW = 68 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: His
• Protein Length: 1-579 a.a.
• Description: Rel B is part of the NFκB complex and forms heterodimeric complexes with p50 (NFKB1) and p52 (NFKB2). The homodimeric complexes of Rel B alone do not show DNA-binding activity. IHC analysis has shown that Rel B expression correlated with dendritic cell activation. NFκB-inducing kinase NIK is required for osteoclastogenesis in response to pathologic stimuli and overexpression of Rel B rescues differentiation of mouse NIK -/- osteoclast precursors. Rel B is required for RANKL-induced osteoclastogenesis in vitro and for TNF -induced bone resorption in vivo. This indicates that the alternative NFκB pathway, via Rel B, plays an essential and unique role in RANKL signaling toward osteoclast development.
• Sequence: Full-length.
• Applications: Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: RELB v-rel reticuloendotheliosis viral oncogene homolog B [ Homo sapiens ]
• Synonyms: RELB; v-rel reticuloendotheliosis viral oncogene homolog B; IREL; I-REL; REL-B; v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3); Transcription factor RelB; I-Rel; reticuloendotheliosis viral oncogene homolog B
• Gene ID: 5971
• mRNA Refseq: NM_006509
• Protein Refseq: NP_006500
• MIM: 604758
• UniProt ID: Q01201
• Chromosome Location: 19q13.32
• Pathway: MAPK signaling pathway
• Function: protein binding; transcription corepressor activity; transcription factor activity