Recombinant Full Length Human OCLN Protein

• Cat.No.: OCLN-352HF
• Product Overview: Recombinant full length Human Occludin with an N terminal proprietary tag; Predicted MWt 83.53 kDa inclusive of tag.

Specification

• Description: This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5.
• Source: In Vitro Cell Free System
• Species: Human
• Form: Liquid
• Molecular Mass: 83.530kDa inclusive of tags
• Protein length: 522 amino acids
• AA Sequence: MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLS QPAYSFYPEDEILHFYKWTSPPGVIRILSMLIIVMCIAIF ACVASTLAWDRGYGTSLLGGSVGYPYGGSGFGSYGSGYGY GYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSV IRSEMSRTRRYYLSVIIVSAILGIMVFIATIVYIMGVNPT AQSSGSLYGSQIYALCNQFYTPAATGLYVDQYSYHYCVVD PQEAIAIVLGFMIIVAFALIIFFAVKTRRKMDRYDKSNIL WDKEHIYDEQPPNVEEWVKNVSAGTQDVPSPPSDYVERVD SPMAYSSNGKVNDKRFYPESSYKSTPVPEVVQELPLTSPV DDFRQPRYSSGGNFETPSKRAPAKGRAGRSKRTEQDHYET DYTTGGESCDELEEDWIREYPPITSDQQRQLYKRNFDTGL QEYKSLQSELDEINKELSRLDKELDDYREESEEYMAAADE YNRLKQVKGSADYKSKKNHCKQLKSKLSHIKKMVGDYDRQ KT
• Purity: Proprietary Purification
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles.
• Storage Buffer: pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione.

Gene Information

• Gene Name: OCLN occludin [ Homo sapiens ]
• Official Symbol: OCLN
• Synonyms: OCLN; occludin; tight junction protein occludin TM4 minus
• Gene ID: 100506658
• mRNA Refseq: NM_001205254
• Protein Refseq: NP_001192183
• MIM: 602876
• UniProt ID: Q16625