OCLN

  • Official Full Name

    occludin

  • Overview

    This gene encodes an integral membrane protein which is located at tight junctions. This protein may be involved in the formation and maintenance of the tight junction. The possibility of several alternatively spliced products has been suggested but the full nature of these products has not been described.

  • Synonyms

    OCLN;occludin;tight junction protein occludin TM4 minus;tight junction protein occludin;BLCPMG;FLJ08163;FLJ18079;FLJ77961;FLJ94056;MGC34277

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • Mouse
  • Dog
  • Mus musculus
  • Xenopus laevis
  • Potorous tridactylus (Potoroo)
  • Pongo Abelii
  • E.coli
  • Wheat Germ
  • HEK293
  • Mammalian Cells
  • In Vitro Cell Free System
  • GST
  • Non
  • DDK
  • Myc
  • His
  • Avi
  • Fc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
OCLN-1440H Recombinant Human OCLN, GST-tagged E.coli Human GST 269-522aa
OCLN-27766TH Recombinant Human OCLN Wheat Germ Human Non 522 amino acids
OCLN-27768TH Recombinant Human OCLN Wheat Germ Human Non 100 amino acids
OCLN-3603H Recombinant Human OCLN protein, MYC/DDK-tagged HEK293 Human DDK&Myc
OCLN-4153R Recombinant Rat OCLN Protein Mammalian Cells Rat His
OCLN-6685C Recombinant Chicken OCLN Mammalian Cells Chicken His
OCLN-3603HCL Recombinant Human OCLN 293 Cell Lysate HEK293 Human Non
Ocln-1882M Recombinant Mouse Ocln Protein, His-tagged E.coli Mouse His Lys264-Pro521
OCLN-2523H Recombinant Human OCLN Protein, His-tagged E.coli Human His Lys266-Thr522
OCLN-352HF Recombinant Full Length Human OCLN Protein In Vitro Cell Free System Human Full L. 522 amino acids
OCLN-3815R Recombinant Rat OCLN Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
OCLN-3815R-B Recombinant Rat OCLN Protein Pre-coupled Magnetic Beads HEK293 Rat
OCLN-3859H Recombinant Human OCLN Protein (Lys266-Thr522), His tagged E.coli Human His Lys266-Thr522
Ocln-425M Recombinant Mouse Ocln Protein, His-tagged E.coli Mouse His Phe17~Ser107
Ocln-4569M Recombinant Mouse Ocln Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
OCLN-9487HFL Recombinant Full Length Human OCLN protein, Flag-tagged Mammalian Cells Human Flag Full L.
RFL15045CF Recombinant Full Length Dog Occludin(Ocln) Protein, His-Tagged E.coli Dog His Full L. Full Length (1-521)
RFL15777MF Recombinant Full Length Mouse Occludin(Ocln) Protein, His-Tagged E.coli Mus musculus His Full L. Full Length (1-521)
RFL1932XF Recombinant Full Length Xenopus Laevis Occludin(Ocln) Protein, His-Tagged E.coli Xenopus laevis His Full L. Full Length (1-493)
RFL2330RF Recombinant Full Length Rat Occludin(Ocln) Protein, His-Tagged E.coli Rat His Full L. Full Length (1-523)
RFL27577GF Recombinant Full Length Chicken Occludin(Ocln) Protein, His-Tagged E.coli Chicken His Full L. Full Length (1-504)
RFL33863HF Recombinant Full Length Human Occludin(Ocln) Protein, His-Tagged E.coli Human His Full L. Full Length (1-522)
RFL35773PF Recombinant Full Length Potorous Tridactylus Occludin(Ocln) Protein, His-Tagged E.coli Potorous tridactylus (Potoroo) His Full L. Full Length (1-489)
RFL6522PF Recombinant Full Length Pongo Abelii Occludin(Ocln) Protein, His-Tagged E.coli Pongo Abelii His Full L. Full Length (1-522)

    Involved Pathway

    OCLN involved in several pathways and played different roles in them. We selected most pathways OCLN participated on our site, such as Apoptosis,Apoptotic cleavage of cell adhesion proteins,Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with OCLN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Leukocyte transendothelial migration PIK3CA,MMP2,RHOH,THY1,PIK3R5,CLDN17,CDH5,CLDN7,PRKCB,ACTG1
    Cell adhesion molecules (CAMs) HLA-DRB4,CNTN1A,CLDN11,CLDN15,CLDN1,CLDND,CLDN18,CLDN22,CD80,CLDNF
    Hepatitis C STAT3,CLDN5,GRB2,Ifna11,IFNA4,BAD,PPP2R2D,IKBKE,PPP2R2C,TRAF2
    Apoptosis PPP3CB,CAPN2A,PPP3CCB,CAPN1A,FAS,PRKACAA,CTNNB1,IL3RA,IL1A,BNIP3LB
    Apoptotic cleavage of cellular proteins DSG1,PLECA,CTNNB1,STK24,PLEC,VIML,CASP6L2,ADD1,SPNA2,DSG2
    Apoptotic execution phase STK24B,CTNNB2,PANK1A,PTBP3,SATB1,HIST1H1B,DSP,DSG2,STK26,DBNLB
    Pathogenic Escherichia coli infection TUBB2A,NCK2,TUBB1,LY96,TUBA1A,ROCK1,ROCK2,TUBAL3,TUBB7P,TUBB
    Apoptotic cleavage of cell adhesion proteins DSP,CTNNB2,DSG2,PKP1,DSG3,CTNNB1,DSG1,PTBP3

    Protein Function

    OCLN has several biochemical functions, for example, protein binding,protein domain specific binding,thiopurine S-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by OCLN itself. We selected most functions OCLN had, and list some proteins which have the same functions with OCLN. You can find most of the proteins on our site.

    Function Related Protein
    protein binding LRP2,LRRC75A-AS1,PPP1R15A,PPEF1,GPSM1,NVL,MAGEA9,SRSF2,RBM41,PHYH
    thiopurine S-methyltransferase activity TPMT.2,TPMT,TPMT.1
    protein domain specific binding NFASC,HIST1H4K,PTPN11,DYNLL1,PICK1,TRP63,CHMP1B,HIST1H4C,HIST2H4,YWHAE

    Interacting Protein

    OCLN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OCLN here. Most of them are supplied by our site. Hope this information will be useful for your research of OCLN.

    CSNK1E;SYNE4;CLEC7A;PLSCR1;CSNK1A1;TJP1;ULK1;SNW1

    Resources

    Research Area

    Tight Junction Proteins in Endothelial Cells
    Tight Junction Proteins in VSMC
    Epithelial Cell Markers and Intracellular Molecules
    gamma delta T Cells
    Tight Junctions

    References

    • Bankwitz, D; Vieyres, G; et al. Role of Hypervariable Region 1 for the Interplay of Hepatitis C Virus with Entry Factors and Lipoproteins. JOURNAL OF VIROLOGY 88:12644-12655(2014).
    • Haid, S; Grethe, C; et al. Isolate-Dependent Use of Claudins for Cell Entry by Hepatitis C Virus. HEPATOLOGY 59:24-34(2014).

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