Recombinant Full Length Human HLA-DQB1 Protein, GST-tagged

• Cat.No.: HLA-DQB1-683HF
• Product Overview: Recombinant full length Human HLA-DQB1(1 a.a. - 261 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ.

Specification

• Species: Human
• Source: In Vitro Cell Free System
• Tag: GST
• ProteinLength: 261 amino acids
• Description: HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants.
• Form: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 56.3 kDa
• AA Sequence: MSWKKALRIP GGLRVATVTL MLAMLSTPVA EGRDSPEDFV YQFKGMCYFT NGTERVRLVT RYIYNREEYA RFDSDVGVYR AVTPLGPPAA EYWNSQKEVL ERTRAELDTV CRHNYQLELR TTLQRRVEPT VTISPSRTEA LNHHNLLVCS VTDFYPAQIK VRWFRNDQEE TTGVVSTPLI RNGDWTFQIL VMLEMTPQRG DVYTCHVEHP SLQNPIIVEW RAQSESAQSK MLSGIGGFVL GLIFLGLGLI IHHRSQKGLL H
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 [ Homo sapiens ]
• Official Symbol: HLA-DQB1
• Synonyms: HLA-DQB1; major histocompatibility complex, class II, DQ beta 1; HLA DQB; HLA class II histocompatibility antigen, DQ beta 1 chain; CELIAC1; IDDM1; MHC DQ beta; MHC class2 antigen; lymphocyte antigen; MHC class II antigen DQB1; MHC class II DQ beta chain; MHC class II antigen HLA-DQ-beta-1; MHC class II HLA-DQ beta glycoprotein; HLA-DQB
• Gene ID: 3119
• mRNA Refseq: NM_001243961
• Protein Refseq: NP_001230890
• MIM: 604305
• UniProt ID: P01920