HLA-DQB1
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Official Full Name
major histocompatibility complex, class II, DQ beta 1 -
Overview
HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1, later, it was among 3 types DQw1 (later DQ1, and split into DQ5 and DQ6), DQw2 and DQw3. Of these three serotyping specificities only DQw1 recognized DQ alpha chain. The serotype is positive in individuals who bear the DQA1*01 alleles. The most frequently found within this group are: DQA1*0101, *0102, *0103, and *0104. In the illustration on the right, DQ1 serotyping antibodies recognizes the DQ alpha (magenta), where antibodies to DQA1* gene products bind variable regions close to the peptide binding pocket. -
Synonyms
CELIAC1;HLA class II histocompatibility antigen, DQ beta 1 chain;HLA DQB;HLA DQB1;IDDM1;Lymphocyte antigen;Major histocompatibility complex class II beta;Major histocompatibility complex, class II, DQ beta 1;MHC class II antigen DQB1;MHC class II antigen HLA DQ beta 1;MHC class II DQ beta chain;MHC class II HLA DQ beta glycoprotein;MHC class2 antigen;MHC DQ beta;OTTHUMP00000029167;OTTHUMP00000178569;OTTHUMP00000178570;OTTHUMP00000178571;HLA-DQB1;DQw1
Recombinant Proteins
- Human
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- GST
- Non
- His
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-DQB1-12H | Recombinant Human HLA-DQB1 protein, GST-tagged | Wheat Germ | Human | GST | 1-261 a.a. |
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| HLA-DQB1-27714TH | Recombinant Human HLA-DQB1 | Wheat Germ | Human | Non | 89 amino acids |
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| HLA-DQB1-802H | Recombinant Human HLA-DQB1 protein, GST-tagged | Wheat Germ | Human | GST | 1-261 a.a. |
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| HLA-DQB1-5496HCL | Recombinant Human HLA 293 Cell Lysate | HEK293 | Human | Non |
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| HLA-DQB1-4097H | Recombinant Human HLA-DQB1 protein, His-tagged | E.coli | Human | His | 33-227aa |
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| HLA-DQB1-673HF | Recombinant Full Length Human HLA-DQB1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 261 amino acids |
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| HLA-DQB1-683HF | Recombinant Full Length Human HLA-DQB1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 261 amino acids |
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Involved Pathway
HLA-DQB1 involved in several pathways and played different roles in them. We selected most pathways HLA-DQB1 participated on our site, such as Phagosome,Cell adhesion molecules (CAMs),Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DQB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Systemic lupus erythematosus | H2AFY2,HIST1H2BO,SNRPD3,CD40LG,HIST1H4E,HIST2H3C2,HLA-DRB1,HIST1H2AJ,HIST1H2BB,GM14483 |
| Cell adhesion molecules (CAMs) | HLA-DRB5,PVRL1,CLDN15LB,CLDN10A,CLDN15,CLDNH,BMA1,H2-Q10,H2-AB1,GLYCAM1 |
| Phagosome | ATP6V1B2,ATP6V0E2,C3A.3,ATP6V1AA,ATP6V0E1,CD209,FCGR3A,FCGR1A,HLA-DOA,ATP6V1H |
| Intestinal i | MHC2DCB,Icosl,CD40,LTBR,MADCAM1,H2-AB1,Il2,HLA-DRB3,CCR9A,CCL27B |
| HTLV-I infection | NRAS,NFKB1,PRKACB,MYBL1,STAT5A,CD3G,ETS1,TBPL2,VCAM1,IL2RB |
| Toxoplasmosis | BCL2,TLR2,MAPK8,LAMA3,PIK3CG,LAMB4,IL12B,GNAI1,MAPK1,IKBKG |
| Autoi | CD86,CD40,IFNA14,IFNA5,PRF1,HLA-DPB1,HLA-DRB3,IFNA2,Fasl,HLA-DQA1 |
| Influenza A | HLA-DOA,TNFRSF10D,IFNA8,CASP1,PRSS1,FURIN,MAPK10,IRF9,IL8L1,FDPS |
| Herpes simplex infection | CLOCKA,TRP53,PPP1CAB,TAP2,IFNA8,THOC4,STAT1B,Ifna11,JAK2B,RELA |
Protein Function
HLA-DQB1 has several biochemical functions, for example, MHC class II receptor activity,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DQB1 itself. We selected most functions HLA-DQB1 had, and list some proteins which have the same functions with HLA-DQB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide antigen binding | MHC1UEA,DHCR24,BF2,H2-AB1,HLA-B,HLA-DRA,HLA-A,HLA-G,HLA-E,TAP1 |
| MHC class II receptor activity | HLA-DQB2,HLA-DPA1,HLA-DRB3,HLA-DOB,HLA-DQA1,KRT17,HLA-DRB1,HLA-DRB4,HLA-DQA2,HLA-DRA |
Interacting Protein
HLA-DQB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DQB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DQB1.
HLA-DQA1
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