Recombinant Full Length Human D2HGDH Protein, GST-tagged

• Cat.No.: D2HGDH-6164HF
• Product Overview: Human MGC25181 full-length ORF ( AAH31817, 1 a.a. - 220 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. [provided by RefSeq, Jul 2008]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 49.94 kDa
• Protein length: 220 amino acids
• AA Sequence: MLGEILSAFEFMDAVCMQLVGRHLHLASPVQESPFYVLIETSGSNAGHDAEKLGHFLEHALGSGLVTDGTMATDQRKVKMLWALRERITEALSRDGYVYKYDLSLPVERLYDIVTDLRARLGPHAKHVVGYGHLGDGNLHLNVTAEAFSPSLLAALEPHVYEWTAGQQGSVSAEHGVGFRKRDVLGYSKPPGALQLMQQLKALLDPKGILNPYKTLPSQA
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: D2HGDH D-2-hydroxyglutarate dehydrogenase [ Homo sapiens (human) ]
• Official Symbol: D2HGDH
• Synonyms: D2HGDH; D-2-hydroxyglutarate dehydrogenase; D2HGD; D-2-hydroxyglutarate dehydrogenase, mitochondrial; EC 1.1.99.-
• Gene ID: 728294
• mRNA Refseq: NM_001287249
• Protein Refseq: NP_001274178
• MIM: 609186
• UniProt ID: Q8N465