Recombinant Active Human D2HGDH Protein, His-tagged, Animal Free
Cat.No. : | D2HGDH-02H |
Product Overview : | Recombinant Active Full length Human D2HGDH Protein (Animal free) with His tag C-Terminus was expressed in E. coli. |
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Species : | Human |
Source : | E.coli |
Tag : | His |
Description : | This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. |
Form : | Lyophilized |
Bio-activity : | The specific activity of D2HGDH is ≥ 90,000 mU/mg. |
Molecular Mass : | 39 kDa |
AA Sequence : | MKVLCYGVRDVELPIFEACNKEFGYDIKCVPDYLNTKETAEMAAGFDAVILRGNCFANKQNLDIYKKLGVKYILTRTAGTDHIDKEYAKELGFPMAFVPRYSPNAIAELAVTQAMMLLRHTAYTTSRTAKKNFKVDAFMFSKEVRNCTVGVVGLGRIGRVAAQIFHGMGATVIGEDVFEIKGIEDYCTQVSLDEVLEKSDIITIHAPYIKENGAVVTRDFLKKMKDGAILVNCARGQLVDTEAVIEAVESGKLGGYGCDVLDGEASVFGKDLEGQKLENPLFEKLVDLYPRVLITPHLGSYTDEAVKNMVEVSYQNLKDLAETGDCPNKIKMGSSHHHHHHSSGLVPRGSHM |
Purity : | ≥ 99% SDS-PAGE |
Applications : | Functional Studies, SDS-PAGE |
Storage : | Shipped at 4 centigrade. Store at +4 centigrade short term (1-2 weeks). Store at -20 centigrade. Avoid freeze/thaw cycle. This product is an active protein and may elicit a biological response in vivo, handle with caution. |
Reconstitution : | Reconstitute in water to a concentration of 0.1-5 mg/mL. The solution can be diluted into other aqueous buffers and stored at –20 centigrade for future use. |
Full Length : | Full L. |
Gene Name | D2HGDH D-2-hydroxyglutarate dehydrogenase [ Homo sapiens (human) ] |
Official Symbol | D2HGDH |
Synonyms | D2HGDH; D-2-hydroxyglutarate dehydrogenase; D2HGD; D-2-hydroxyglutarate dehydrogenase, mitochondrial; EC 1.1.99.39 |
Gene ID | 728294 |
mRNA Refseq | NM_152783 |
Protein Refseq | NP_689996 |
MIM | 609186 |
UniProt ID | D2RJU7 |
◆ Recombinant Proteins | ||
D2HGDH-2180M | Recombinant Mouse D2HGDH Protein, His (Fc)-Avi-tagged | +Inquiry |
D2HGDH-1752HFL | Recombinant Full Length Human D2HGDH Protein, C-Flag-tagged | +Inquiry |
D2HGDH-4339H | Recombinant Human D2HGDH Protein, GST-tagged | +Inquiry |
D2HGDH-627H | Recombinant Human D2HGDH Protein, Myc/DDK-tagged, C13 and N15-labeled | +Inquiry |
D2HGDH-5093Z | Recombinant Zebrafish D2HGDH | +Inquiry |
◆ Cell & Tissue Lysates | ||
D2HGDH-7088HCL | Recombinant Human D2HGDH 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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