Recombinant COVID-19 NSP3 protein, His-tagged

• Cat.No.: NSP3-362V
• Product Overview: Recombinant COVID-19 NSP3 protein (Glu1564-IIe1877) was fused to His-tag at the N-terminus and expressed in E.coli.

Specification

• Species: Sars-CoV-2
• Source: E.coli
• Tag: His
• Protein Length: Glu1564-IIe1877
• Description: The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Targeting PLpro with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells.
• Form: Supplied as solution form in sterile PBS, pH7.5, 4M urea.
• Molecular Mass: Predicted Molecular Mass: 38.59 kDa; Actual Molecular Mass: 34 kDa.
• Purity: >90% as determined by SDS-PAGE.
• Applications: Immunogen.
• Notes: For research ues only. Not for use in clinical diagnostic procedures.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2-8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Concentration: 1.0 mg/ml
• Shipping: In general, proteins are shipped out with blue ice unless customers require otherwise.

Gene Information

• Gene Name: orf1ab
• Official Symbol: orf1ab
• Synonyms: pp1ab; PL-PRO, Papain-like proteinase, X domain
• Gene ID: 1489680
• Protein Refseq: NP_828862.2
• UniProt ID: P0C6X7