Recombinant COVID-19 NSP3 protein, His-tagged

• Cat.No.: NSP3-81V
• Product Overview: Recombinant COVID-19 NSP3 full length or partial length protein was fused to His-tag and expressed in HEK293.

Specification

• Species: COVID-19
• Source: HEK293
• Tag: His
• Description: Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3. Prevents also host NF-kappa-B signaling.
• Form: PBS, pH7.4.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: >80%
• Storage: Store it at 4 ºC for short time. For long term storage, store it at -20ºC to -80ºC.
• Warning: For Research Use Only.

Gene Information

• Gene Name: orf1ab
• Official Symbol: orf1ab
• Synonyms: pp1ab
• Gene ID: 1489680
• Protein Refseq: NP_828862.2
• UniProt ID: P0C6X7