Rabbit Anti-Human PDCD4 Polyclonal Antibody

• Cat.No.: CPBT-56410RH
• Product Overview: Rabbit Polyclonal antibody to Human PDCD4.

Specification

• Cat. No.: CPBT-56410RH
• Antigen Description: This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.
• Isotype: IgG
• Immunogen: Synthetic peptide conjugated to KLH derived from within residues 450 to the C-terminus of Human PDCD4.
• Host: Rabbit
• Species: Human
• Specificity: Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.
• Formulation: Liquid
• Purity Detail: Immunogen affinity purified
• Applications: ICC/IF, WB
• Storage buffer: Preservative: 0.02% Sodium AzideConstituents: 1% BSA, PBS, pH 7.4
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequence similarities: Belongs to the PDCD4 family.Contains 2 MI domains.
• Tag: Non

Gene Information

• Gene Name: PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) [ Homo sapiens ]
• Official Symbol: PDCD4
• Synonyms: PDCD4; H731; MGC33046; MGC33047; programmed cell death 4 (neoplastic transformation inhibitor); programmed cell death protein 4; protein 197/15a; nuclear antigen H731; neoplastic transformation inhibitor protein; Nuclear antigen H731-like
• Gene ID: 27250
• mRNA Refseq: NM_014456
• Protein Refseq: NP_055271
• MIM: 608610
• UniProt ID: Q53EL6
• Chromosome Location: 10q24
• Pathway: mTOR signaling pathway
• Function: RNA binding; binding; protein binding

Reviews

04/03/2021

Good solubility and stability in solution.

01/27/2021

The purity is good, and the results obtained after analysis by SDS-PAGE or Western blot are good.

01/12/2021

Short half-life and high clearance.

Q&As

Can PDCD4 be used as a target for sequencing signals?

Yes, PDCD4 is involved in the regulation of NF-κB signaling pathway and other biological processes of sequencing signals, and can be a target for sequencing signals.

How can changes in the expression and function of PDCD4 be assessed?

Immunodeficiency method, Western blot, fluorescence microscopy and other techniques can be used to evaluate the changes in the expression and function of PDCD4.

What is the role of PDCD4 in intestinal disease?

It may be involved in processes such as proliferation, apoptosis, and inflammatory response of intestinal epithelial cells, and is associated with intestinal diseases.

What is the role of PDCD4 in neurological disorders?

PDCD4 may be related to neuronal apoptosis, neuroinflammatory response, etc. in neurological diseases.

What is the relationship between PDCD4 and liver disease?

PDCD4 is involved in the regulation of hepatocyte growth, apoptosis and transformation, and may play a role in the occurrence and development of liver diseases.

How can the information from PDCD4 be used for the development of therapeutic strategies?

Through in-depth study of the signaling pathways and regulatory mechanisms of PDCD4, we can provide important clues for the development of therapeutic strategies for related diseases.