Native Mouse Coagulation Factor II

• Cat.No.: F2-5287M
• Product Overview: Mouse F2 isprepared from fresh frozen mouse plasma.

Specification

• Species: Mouse
• Source: Mouse Plasma
• Tag: Non
• Description: F2is proteolytically cleaved to form thrombin in the first step of thecoagulation cascade, which ultimately results in the stemming of blood loss.F2 in turn acts as a serine protease that converts soluble fibrinogen intoinsoluble strands of fibrin, as well as catalyzing many other coagulation-relatedreactions.
• Form: Frozenliquid in 0.05 M HEPES Buffer + 0.1 M NaCl, pH 7.4.
• Purity: > 95% by SDS-PAGEanalysis.
• MolecularWeight: 72 kDa
• EndotoxinLevel: < 0.1ng/μg of protein
• Biological Activity: Activityis measured by clotting and/or chromogenic substrate assay, following conversionof prothrombinto thrombin.
• Concentration: 5.0mg/ml
• Storage: Store at -80°C. Stable for 3 years from delivery. Avoid repeated freeze-thaw cycles.
• Pathways: BloodClotting Cascade; Cell surface interactions at the vascular wall; ClassA/1(Rhodopsin-like receptors); Common Pathway; Complement and CoaqulationCascades; Diabetes pathways; FOXA2 and FOXA3 transcription factor networks; ExtrinsicPathway; Formation of Fibrin Clot (Clotting Cascade); Hemostasis; IntrinsicPathway; Regulation of actin cytoskeleton; Selenium Pathway; SignalTransduction

Gene Information

• Gene Name: F2coagulation factor II [ Mus musculus ]
• Official Symbol: F2
• Synonyms: F2; coagulation factor II;prothrombin; thrombin; Cf2; FII; Cf-2; OTTMUSP00000015068; EC 3.4.21.5;Prothrombin; Coagulation factor II; Thrombin light chain; Thrombin heavychain
• Gene ID: 14061
• mRNA Refseq: NM_010168
• Protein Refseq: NP_034298
• UniProt ID: P19221
• Chromosome Location: 2
• Function: peptidaseactivity;serine-typeendopeptidase activity; calcium ion binding; receptor binding; thrombospondinreceptor activity; catalytic activity; hydrolase activity; serine-type peptidaseactivity