Native Human Coagulation Factor II

• Cat.No.: F2-1882H
• Product Overview: Native human F2 was expressedin Human plasma.

Specification

• Description: F2 is aserine protease protein that in humans is encoded by the F2 gene. Prothrombin(coagulation factor II) is proteolytically cleaved to form thrombin in thefirst step of the coagulation cascade, which ultimately results in thestemming of blood loss. F2 in turn acts as a serine protease that convertssoluble fibrinogen into insoluble strands of fibrin, as well as catalyzingmany other coagulation-related reactions.
• Source: Human Plasma
• Species: Human
• Form: Liquid in 0.1 MNaH2P04, pH 6.5.
• Molecular Mass: 35.4 kDa
• Storage: Store in workingaliquots at -20°C . Avoid repeated freeze-thaw cycles.
• Concentration: 5.0 mg/ml
• Tag: Non

Gene Information

• Gene Name: F2 coagulation factor II (thrombin) [ Homo sapiens ]
• Official Symbol: F2
• Synonyms: F2; coagulation factor II (thrombin); prothrombin; serine protease; prothrombin B-chain; PT; THPH1
• Gene ID: 2147
• mRNA Refseq: NM_000506
• Protein Refseq: NP_000497
• MIM: 176930
• UniProt ID: P00734
• Chromosome Location: 11p11-q12
• Pathway: Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem
• Function: calcium ion binding; growth factor activity; peptidase activity; protein binding; receptor binding; contributes_to receptor binding; serine-type endopeptidase activity; thrombospondin receptor activity

Reviews

01/01/2022

Quality control is evident. This product ensures accuracy in our studies.

01/27/2019

Our lab swears by this protein. Fast shipping is a definite bonus.

12/18/2018

Consistently reliable. The shipping speed is appreciated in our fast-paced lab.

Q&As

Can you discuss the role of the F2 gene in the synthesis of vitamin K-dependent clotting factors, and how disruptions in this process may lead to coagulation disorders?

The F2 gene plays a crucial role in the synthesis of vitamin K-dependent clotting factors, including prothrombin. Disruptions in this process, often due to genetic or nutritional factors, can contribute to coagulation disorders, impacting hemostasis and blood clotting.

How is the F2 gene regulated at the transcriptional level, and what factors influence prothrombin synthesis in hepatocytes?

Transcriptional regulation of the F2 gene involves factors like vitamin K-dependent gamma-carboxylation. Hepatocytes synthesize prothrombin under the influence of vitamin K and other coagulation factors.

The F2 gene encodes prothrombin, a crucial factor in blood coagulation. Prothrombin is converted to thrombin, a key enzyme in the clotting cascade, facilitating fibrin formation.

The F2 gene encodes prothrombin, a crucial factor in blood coagulation. Prothrombin is converted to thrombin, a key enzyme in the clotting cascade, facilitating fibrin formation.

What are the implications of genetic variations in the F2 gene, particularly polymorphisms, on prothrombin function and susceptibility to thrombotic or bleeding disorders?

Genetic variations in F2, including polymorphisms, can influence prothrombin function. Certain variants may predispose individuals to thrombotic or bleeding disorders.

How does genetic variation in the F2 gene impact prothrombin levels, and what are the consequences for an individual's risk of thrombotic events?

Genetic variations in the F2 gene can influence prothrombin levels, affecting an individual's propensity for thrombotic events. Certain variants may predispose individuals to a higher or lower risk of abnormal blood clot formation.