Native Human Von Willebrand Factor

• Cat.No.: VWF-369H
• Product Overview: Native human VWF isprepared from citrated human plasma using a combination of chromotographicprocedures.

Specification

• Species: Human
• Source: Human Plasma
• Tag: Non
• Description: Von Willebrandfactor is prepared from citrated human plasma using a combination ofchromotographic procedures. The preparations consist of large multimers asdetermined by electrophoresis in SDS/agarose gels. Molecular weight is 250000(monomer), 1-20 X 1000000 (multimers).
• Form: Frozen liquid in abuffer of 0.025M Sodium Citrate + 0.1M NaCl + 0.1M glycine, pH 6.8.
• Purity: >95% pure bySDS-PAGE under reducing conditions.
• MolecularWeight: 260 kDa (Monomer)
• Concentration: 0.2 mg/ml
• Certification: Although thestarting material was tested prior to initiation of the manufacturing processand was found negative or nonreactive for anti-HIV-1/2, HIV-1 antigen(s),HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II, extreme cautionshould be used when handling this material as there is a margin of error inall tests.
• Storage: Store at -80°C. Thawin a 37°C water bath for 2-3 minutes without agitation.
• OfficialSymbol: VWF
• Pathways: Blood ClottingCascade; Complement and Coagulation Cascades; ECM-receptor interaction; FocalAdhesion; Formation of Fibrin Clot (Clotting Cascade); GP1b-IX-V activationsignalling; Hemostasis; Integrin alphaIIb beta3 signaling; Integrin cellsurface interactions; Intrinsic Pathway; Platelet Adhesion to exposedcollagen; Platelet Aggregation (Plug Formation); Platelet activation;Platelet degranulation

Gene Information

• Gene Name: VWF von Willebrand factor [ Homosapiens ]
• Synonyms: VWF; vonWillebrand factor; VWD; F8VWF; coagulation factor VIII VWF; von Willebrand antigen II
• Gene ID: 7450
• mRNA Refseq: NM_000552
• Protein Refseq: NP_000543
• MIM: 613160
• UniProt ID: P04275
• Chromosome Location: 12p13.3
• Function: chaperone binding;collagen binding; glycoprotein binding; immunoglobulin binding; integrinbinding; protease binding; protein N-terminus binding; protein binding;protein homodimerization activity