Native Human TG

• Cat.No.: TG-31519TH
• Product Overview: Full length native Human Thyroglobulin purified from Human thyroid tissue, amino acids 20-2768 , predicted MWt 303kDa.

Specification

• Description: Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.
• Protein length: 2749 amino acids
• Molecular Weight: 303.000kDa
• Tissue specificity: Thyroid gland specific.
• Form: Lyophilised:Use of phosphate buffer, pH >7.0 containing 0.15M NaCl is recommended.
• Purity: by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 0.02M Ammonium bicarbonate. May contain traces of buffer salts.
• Storage: Store at +4°C.
• Sequence Similarities: Belongs to the type-B carboxylesterase/lipase family.Contains 11 thyroglobulin type-1 domains.
• Tag: Non

Gene Information

• Gene Name: TG thyroglobulin [ Homo sapiens ]
• Official Symbol: TG
• Synonyms: TG; thyroglobulin; AITD3; TGN
• Gene ID: 7038
• mRNA Refseq: NM_003235
• Protein Refseq: NP_003226
• MIM: 188450
• Uniprot ID: P01266
• Chromosome Location: 8q24
• Pathway: Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem
• Function: NOT carboxylesterase activity; chaperone binding; hormone activity; NOT neurexin family protein binding; NOT receptor activity