TG
-
Official Full Name
thyroglobulin -
Overview
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. -
Synonyms
TG;thyroglobulin;TGN;AITD3;Thyroglobulin;Tg
Recombinant Proteins
- Human
- Porcine
- Mouse
- Bovine
- Rat
- Pig
- E.coli
- Porcine
- Human Thyroids
- Mammalian Cell
- Human
- Wheat Germ
- HEK293 cells
- Bovine Thyroid
- Pig
- Porcine thyroid gland
- HEK293T
- HEK293
- GST
- Non
- His
- His&SUMO
- Myc&DDK
- His&Fc&Avi
Involved Pathway
TG involved in several pathways and played different roles in them. We selected most pathways TG participated on our site, such as Thyroid hormone synthesis,Autoi,ne thyroid disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with TG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone synthesis | ATP1A3,PLCB4,HSP90B1,ATP1B3,ATP1A1,PRKACA,TPO,CREB3L3,CREB5,ATP1B4 |
| Autoi | HLA-DQA1,H2-Q10,IFNA2,TSHR,IFNA1,HLA-A,IL4,FASLG,HLA-DRB1,Ifna11 |
| ne thyroid disease | IL5,HLA-C,H2-AA,CD40,HLA-DQB1,H2-AB1,IFNA6,IFNA1,HLA-DPB1,Fasl |
Protein Function
TG has several biochemical functions, for example, anion binding,chaperone binding,hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TG itself. We selected most functions TG had, and list some proteins which have the same functions with TG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | SYT16,BOK,IDE,IL12B,TYRP1,CADM2,CADM2A,TBX18,CEACAM5,DPY30 |
| protein complex binding | HADHA,GNB4,PTK2B,C8B,MLKL,AP2A2,CDKN1A,PRMT5,C8G,CALY |
| hormone activity | INHA,MLN,PRL3C1,LEPB,PRL2A1,INSL5A,CRHB,METRNL,PRL2C2,IGF1 |
| chaperone binding | SOD1,BIRC5,DNAJB4,HSPA5,DNAJA3B,TSC1,AHSA1,PIH1D3,DNAJB1,SYVN1 |
Interacting Protein
TG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TG here. Most of them are supplied by our site. Hope this information will be useful for your research of TG.
carB;q81xd7_bacan
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References
- Toyota, H; Sudo, K; et al. Thy28 protects against anti-CD3-mediated thymic cell death in vivo. APOPTOSIS 20:444-454(2015).
- Mukai, T; Gallant, R; et al. Loss of SH3 Domain-Binding Protein 2 Function Suppresses Bone Destruction in Tumor Necrosis Factor-Driven and Collagen-Induced Arthritis in Mice. ARTHRITIS & RHEUMATOLOGY 67:656-667(2015).
