Native Human KNG1

• Cat.No.: KNG1-29146TH
• Product Overview: Full length native Human LMW Kininogen purified from Human Plasma; MWt 65 kDa.

Specification

• Species: Human
• Source: Human Plasma
• Tag: Non
• Description: This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.
• Form: Lyophilised
• Molecular Mass: 65 kDa
• Purity: >95% by SDS-PAGE
• Storage: Shipped at 4°C . Store at -20°C .
• Storage Buffer: Preservative: NoneConstituents: 200mM Sodium chloride, 10mM Sodium acetate, pH 5.5
• Full Length: Full L.

Gene Information

• Gene Name: KNG1 kininogen 1 [ Homo sapiens ]
• Official Symbol: KNG1
• Synonyms: KNG1; kininogen 1; BDK, kininogen , KNG; kininogen-1; alpha 2 thiol proteinase inhibitor; bradykinin; HMWK; fitzgerald factor; high molecular weight kininogen; alpha-2-thiol proteinase inhibitor; williams-Fitzgerald-Flaujeac factor; BDK; KNG
• Gene ID: 3827
• mRNA Refseq: NM_000893
• Protein Refseq: NP_000884
• MIM: 612358
• UniProt ID: P01042
• Chromosome Location: 3q21-qter
• Pathway: ACE Inhibitor Pathway, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem
• Function: cysteine-type endopeptidase inhibitor activity; heparin binding; peptidase inhibitor activity; receptor binding; zinc ion binding