KNG1
-
Official Full Name
Kininogen Heavy Chain -
Overview
Kininogens are inhibitors of thiol proteases. HMW Kininogen plays an important role in blood coagulation by helping to position optimally pre-Kallikrein and Factor XI next to Factor XII. HMW Kininogen inhibits the Thrombin- and Plasmin-induced aggregation of thrombocytes; the active peptide Bradykinin that is released from HMW Kininogen shows a variety of physiological effects: influence in smooth muscle contraction, induction of hypotension, natriuresis and diuresis and decrease in blood glucose level. It is also a mediator of inflammation and causes increase in vascular permeability, stimulation of nociceptors release of other mediators of inflammation (e.g. Prostaglandins) and it has a cardioprotective effect (directly via Bradykinin action, indirectly via endothelium-derived relaxing factor action). -
Synonyms
HMWK light chain;Kininogen 1;Kininogen 1 light chain;KNG;KNG1
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- Human Plasma
- HEK293
- Mammalian Cells
- E.coli
- Human Cells
- Mouse
- Yeast
- Wheat Germ
- In Vitro Cell Free System
- Non
- His
- GST&His
- His&T7
- DDK&Myc
- Avi&Fc&His
- GST
- Flag
Involved Pathway
KNG1 involved in several pathways and played different roles in them. We selected most pathways KNG1 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with KNG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Complement and coagulation cascades | MASP1,SERPINC1,SERPINA1,F12,C7,C8G,SERPIND1,F13B,CD59,LOC100514666 |
Protein Function
KNG1 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity,heparin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KNG1 itself. We selected most functions KNG1 had, and list some proteins which have the same functions with KNG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heparin binding | FMODA,CXCL6,LRPAP1,Epy,Itgam&Itgb2,COMP,NDNF,SERPINA10,SERPINA5,ANG |
| cysteine-type endopeptidase inhibitor activity | NGP,CST6,BIRC7,SERPINB3,AHSG1,BIRC5,AHSG,BIRC5A,CST4,STFA2 |
| zinc ion binding | SETDB1B,Npepo,RNF115,PIAS4A,TRIM32,MMP14,S100A8,ZRANB3,CA2,S100A9 |
| receptor binding | PVRL2L,FGF18B,A2M,CCL13,CROT,GNPAT,FLT3LG,CTNND1,CCL2,WNT7A |
| protein binding | C18orf1,EDNRA,GOLPH3,PSMA1,CTDSP1,HAPLN2,CHD1,PGBD1,KIF14,FAM153C |
Interacting Protein
KNG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KNG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KNG1.
Ance;C1QBP;F12;KLKB1;Lamc1;Lamb1;Lama1;Lama5;Lamb2;p29991-pro_0000037946;d-mannose
Resources
Research Area
Neurotransmitter Associated EnzymesCoagulation Cascade Protease Inhibitors
Kinin System
Plasmin/Plasminogen and Kallikrein/Kinin Systems
Related Services
Related Products
References
- Lieb, W; Chen, MH; et al. Genome-Wide Meta-Analyses of Plasma Renin Activity and Concentration Reveal Association With the Kininogen 1 and Prekallikrein Genes. CIRCULATION-CARDIOVASCULAR GENETICS 8:131-U278(2015).
- Bruzelius, M; Bottai, M; et al. Predicting venous thrombosis in women using a combination of genetic markers and clinical risk factors. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 13:219-227(2015).
