Native Human Cathepsin G

• Cat.No.: CTSG-5327H
• Product Overview: Native Human CTSG was expressed in Human Neutrophil.

Specification

• Species: Human
• Source: Human Neutrophil
• Tag: Non
• Description: CTSG, is a serine protease, and a member of thepeptidase S1 protein family, located in the azurophil granules of neutrophils.Studies have shown that CTSG when released from granulocytes binds to NKcells and augments NK cytotoxicity through its protease activity. CTSG has aspecificity similar to that of Chymotrypsin C, and may participate in thekilling and digestion of engulfed pathogens, and in connective tissueremodeling at sites of inflammation. Transcript variants utilizingalternative polyadenylation signals exist for this gene.
• Form: Liquid in50 mM Sodium Acetate pH 5.5 + 0.8 M NaCl.
• Biological Activity: One unit willhydrolyze one micromole ofSuccinyl-alanine-alanine-proplinephenylalanine-p-nitroanilide per minute at37°C and pH 7.5.
• Concentration: Typically > 0.1mg/ml
• Storage: Product is stable at -80°Cfor 3 years.
• OfficialSymbol: CTSG
• Pathways: ACE Inhibitor Pathway; Lysosome; Amoebasis;Diabetes; Neuroactive ligand-receptor interaction; Renin-angiotensin system;Systemic lupus erythematosus

Gene Information

• Gene Name: CTSGcathepsin G [ Homo sapiens ]
• Synonyms: CTSG; cathepsinG; CG; CATG; MGC23078; OTTHUMP00000178752; EC 3.4.21.20; Cathepsin G
• Gene ID: 1511
• mRNA Refseq: NM_001911
• Protein Refseq: NP_001902
• MIM: 116830
• UniProt ID: P08311
• Chromosome Location: 14q11.2
• Function: serine-typeendopeptidase activity; heparin binding; peptidase activity