CTSG
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Official Full Name
cathepsin G -
Overview
Cathepsin G is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSG gene. The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. Transcript variants utilizing alternative polyadenylation signals exist for this gene. -
Synonyms
cathepsin G;CTSG;CG;CATG;MGC23078;OTTHUMP00000178752;CATG_HUMAN;Cathepsin G precursor;CTSG protein;EC 3.4.21.20;EC 3.4.21
Recombinant Proteins
- Human
- Mouse
- Rat
- Human Neutrophil
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- Non
- His&GST
- His
- GST
- His&Fc&Avi
- His&SUMO
Involved Pathway
CTSG involved in several pathways and played different roles in them. We selected most pathways CTSG participated on our site, such as ACE Inhibitor Pathway,Activation of Matrix Metalloproteinases,Amoebiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Amoebiasis | Casp3,PRKACG,GNAS,PRKACB,IL-8,ITGB2,GNA15,LAMC2,IL1R2,SERPINB1 |
| Activation of Matrix Metalloproteinases | MMP11,CTSL2,MMP8,MMP10,MMP24,CTSK,MMP15,MGC174857,CTRB1,TIMP2B |
| Extracellular matrix organization | EFEMP1,COL17A1,COL8A1,COL15A1B,COL28A1,ABHD1,COL25A1,MMP24,ASPN,NID2 |
| ACE Inhibitor Pathway | ATP6AP2,AGTR1,CMA1,AGTR2,CYP11B2,AGT,ACE |
| Degradation of the extracellular matrix | MGC174152,BMP1B,COL23A1,ADAMTS8,BMP1A,MMP12,MMP15,CTSD,TLL2,COL25A1 |
| Metabolism of Angiotensinogen to Angiotensins | CPB2,GZMH,CMA1,CPB1,ACE,ATP6AP2,CPA3 |
| Metabolism of proteins | ADAMTS15,MIA3,ST6GALNAC1.2,APEH,EIF5,FBXW5,RHBDL1,EXOC6,ZNF408,BET1 |
| Lysosome | ATP6AP1,ASAH1B,AP3B1,AP3S2,ATP6V0A2,GBA,LGMN,AP3S1,GNSA,NAGLU |
Protein Function
CTSG has several biochemical functions, for example, heparin binding,peptidase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSG itself. We selected most functions CTSG had, and list some proteins which have the same functions with CTSG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | C16orf45,WDR20,PEF1,RPF1,MAPKAPK2,ZNF643,ZRANB1,FIG4,MOS,TEAD4 |
| peptidase activity | CAPN2L,MEP1A.2,USPL1,ST14A,CTSSA,FAM105B,USP9,CTSBB,FURINA,OTUD4 |
| heparin binding | PLA2G5,PF4,FGFR4,MMP7,APLP1,Itgam&Itgb2,FGF7,VEGFAA,BMP7,LIPG |
| serine-type endopeptidase activity | PRSS46,CTRL,GZME,PRSS22,PCSK9,CELA1,PLAT,TMPRSS13B,CFB,CELA3A |
Interacting Protein
CTSG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSG here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSG.
KRT31;NOTCH2NL;dsdna_dcmdg:dcmdg;A2M;P/V/C
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References
- Xu, C; Wang, JJ; et al. Adsorption of uranium by amidoximated chitosan-grafted polyacrylonitrile, using response surface methodology. CARBOHYDRATE POLYMERS 121:79-85(2015).
- Liu, GL; Li, DG; et al. Reconstruction of real tooth surfaces of spiral bevel pinions with modified offset. INVERSE PROBLEMS IN SCIENCE AND ENGINEERING 23:214-234(2015).
