Native Human A2M Protein

• Cat.No.: A2M-01H
• Product Overview: Human Alpha-2 Macroglobulin is a tetrameric glycoprotein, purified from Human plasma.

Specification

• Species: Human
• Source: Human Plasma
• Protein Length: Full Length
• Description: The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.
• Form: Sterile Filtered White lyophilized (freeze-dried) powder.
• Solubility: It is recommended to reconstitute the lyophilized A2M in sterile 18MΩ-cm H2O.
• Molecular Mass: 725 kDa
• Purity: Greater than 96.0 %
• Note: For Research Use Only. Not for use in diagnostic procedures.
• Storage: Human Alpha-2 Macroglobulin although stable at room temperature for 3 weeks, should be stored between 2-8 centigrade. Do not freeze!
• Storage Buffer: Lyophilized from 0.02M TRIS, 0.15M NaCl and 0.1M Sucrose, pH 8.0.

Gene Information

• Gene Name: A2M alpha-2-macroglobulin [ Homo sapiens (human) ]
• Official Symbol: A2M
• Synonyms: A2M; alpha-2-macroglobulin; CPAMD5; FWP007; S863 7; alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; A2MD; S863-7; DKFZp779B086
• Gene ID: 2
• mRNA Refseq: NM_000014
• Protein Refseq: NP_000005
• MIM: 103950
• UniProt ID: P01023