Active Recombinant Mouse Osm

• Cat.No.: Osm-8302M
• Product Overview: Recombinant Mouse Osm was expressed in E. coli.

Specification

• Description: Oncostatin M (OSM) is a pleitropic cytokine produced by activated T lymphocytes and monocytes that is structurally and functionally related to the subfamily of cytokines known as the IL-6-type cytokine family.?OSM either inhibits or enhances the growth of cells depending on cell type. It inhibits proliferation of skeletal muscle cells by blocking cell cycle progression from G(1) to S phase.?OSM is also a key mediator for proliferation and anti-apoptosis of hepatocytes which suggests that OSM gene therapy is useful, as preventive and curative means, for the treatment of patients with liver damage.
• Source: E. coli
• Species: Mouse
• Form: This recombinant protein was 0.2 μm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
• Bio-activity: The biological activity of Mouse OSM was measured in a cell proliferation assay using NIH/3T3 mouse embryonic fibroblasts. The expected ED50= 0.25-1.0 ng/ml.
• Molecular Mass: The predicted molecular weight of Recombinant Mouse OSM is Mr 21 kDa.
• AA Sequence: manrgcsn sssqllsqlq nqanltgnte sllepyirlq nlntpdlraa ctqhsvafps edtlrqlskp hflstvyttl drvlyqldal rqkflktpaf pkldsarhni lgirnnvfcm arllnhslei peptqtdsga srstttpdvf ntkigscgfl wgyhrfmgsv grvfrewddg strsrr
• Endotoxin: <0.1 eu/μg="" as="" determined="" by="" the="" lal="">
• Purity: >97% by SDS-PAGE and analyzed by silver stain.
• Storage: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
• Tag: Non

Gene Information

• Gene Name: Osm oncostatin M [ Mus musculus ]
• Official Symbol: Osm
• Synonyms: OSM; oncostatin M; oncostatin-M; OncoM
• Gene ID: 18413
• mRNA Refseq: NM_001013365
• Protein Refseq: NP_001013383
• Pathway: Adipogenesis, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem
• Function: cytokine activity; cytokine activity; growth factor activity; oncostatin-M receptor binding