Active Recombinant Mouse Alkaline Phosphatase, Liver/Bone/Kidney, His-tagged
| Cat.No. : | Alpl-444M |
| Product Overview : | Recombinant Mouse Alplprotein was expressed in Murine myeloma cell line. Phe18-Gly503, witha C terminal 6 His tag. |
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| Cat. No. : | Alpl-444M |
| Description : | Severaldistinct genes encode alkaline phosphatases (APs) in mice with differenttissuespecific expression patterns. The Alpl gene, also known as Akp2,encodes the liver/bone/kidney isozyme, also known as the tissuenonspecific AP(TNAP). The Alpl gene is a key regulator of bone mineralization in mice. Avariety of mutations in the human Alpl gene leads todifferent forms of hypophosphatasia, characterized by poorly mineralizedcartilage and bones. |
| Source : | Mammalian cells |
| Form : | Suppliedas a 0.2 um filtered solution in Tris and NaCl. |
| N-terminalSequence : | Phe18 |
| MolecularWeight : | 54 kDa |
| Activity : | Measuredby its ability to cleave a fluorogenic substrate, 4Methylumbelliferyl phosphate(4MUP). The specific activity is > 40000 pmoles/min/μg, as measured underthe described conditions. See Activity Assay Protocol. |
| Endotoxin Level : | <1.0EU per 1 μg of the protein by the LAL method. |
| Purity : | >95%,by SDSPAGE under reducing conditions and visualized by silver stain. |
| Storage : | Do notfreeze. 3months from date of receipt, 2 to 8°C as supplied. 1 month, 2 to 8°C understerile conditions after opening. |
| Protein length : | 18-503 a.a. |
| Gene Name | Alpl alkaline phosphatase,liver/bone/kidney [ Mus musculus ] |
| Official Symbol | Alpl |
| Synonyms | Alpl; alkalinephosphatase, liver/bone/kidney; Akp2; TNAP; Akp-2; APTNAP; TNSALP; alkalinephosphatase, tissue-nonspecific isozyme; alkaline phosphatase 2, liver; EC 3.1.3.1 |
| Gene ID | 11647 |
| mRNA Refseq | NM_007431 |
| Protein Refseq | NP_031457 |
| UniProt ID | P09242 |
| Chromosome Location | 4 |
| Pathway | Endochondral Ossification;Folate biosynthesis; Metabolic pathways; TNF-alpha NF-kB Signaling Pathway |
| Function | alkaline phosphataseactivity; catalytic activity; hydrolase activity; metal ion binding; phosphataseactivity |
Not For Human Consumption!
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