ALPL
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Official Full Name
alkaline phosphatase, liver/bone/kidney -
Overview
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and;liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue;non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is;not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme.;The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the;enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal;development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by;hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the;specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript;variants have been described. -
Synonyms
ALPL;alkaline phosphatase, liver/bone/kidney;HOPS;alkaline phosphatase, tissue-nonspecific isozyme;TNSALP;glycerophosphatase;tissue-nonspecific ALP;alkaline phosphomonoesterase;liver/bone/kidney-type alkaline phosphatase;alkaline phosphatase live
Recombinant Proteins
- Human
- Mouse
- Calf
- Zebrafish
- Rhesus macaque
- Rat
- Chicken
- Cattle
- HEK293
- E.coli
- Mammalian cells
- Human placenta
- Human Liver
- Calf Intestine
- Mammalian Cell
- Wheat Germ
- Human Cell
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- Fc
- Myc&DDK
- His&Fc&Avi
- Flag
- His&SUMO
Involved Pathway
ALPL involved in several pathways and played different roles in them. We selected most pathways ALPL participated on our site, such as Folate biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALPL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Folate biosynthesis | MOCS1,PTS,SPRA,ALPI.1,QDPRA,QDPR,ALPI,GCH1,GGH,DHFRL1 |
| Metabolic pathways | ACSM2B,MVDA,XYLT2,CCBL1,KHK,PGM2,PLCG2,HSD17B7,GPI1,ATP6V0C |
Protein Function
ALPL has several biochemical functions, for example, alkaline phosphatase activity,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALPL itself. We selected most functions ALPL had, and list some proteins which have the same functions with ALPL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alkaline phosphatase activity | ALP3,ALPI.1,ALPP,ALPPL2,ALPI |
| metal ion binding | MFNG,ZNF643,ZNF454,CPEB1,SAP30L,KLK1B4,ATP1A3A,FYNB,RNF11A,NR1D4B |
| protein binding | KCP,PTBP3,KCNE4,ADCY6,RBFOX2,TRP53,NMRK2,UBE2D4,PIPOX,SETDB1 |
| pyrophosphatase activity | PRUNE2,CANT1A,GMPS,PHOSPHO1,DOM3Z,NUDT19,CANT1B |
Interacting Protein
ALPL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALPL here. Most of them are supplied by our site. Hope this information will be useful for your research of ALPL.
MAP3K14;TRAF2;TRAF3;EIF4A2;lrp;NFKBIA;RELA
Resources
Research Area
Phosphatases and RegulatorsOsteoclast Markers
Embryonic and Induced Pluripotent Stem Cell Markers
Osteoblast and Osteoclast Markers
Related Services
Related Products
References
- Xie, M; Xing, GF; et al. Functional role of EMMPRIN in the formation and mineralisation of dental matrix in mouse molars. JOURNAL OF MOLECULAR HISTOLOGY 46:21-32(2015).
- Maeland, JA; Radtke, A; et al. Comparison of Z and R3 antigen expression and of genes encoding other antigenic markers in invasive human and bovine Streptococcus agalactiae strains from Norway. VETERINARY MICROBIOLOGY 167:729-733(2013).
