Active Recombinant Human TEK protein (R915C), GST-tagged
Cat.No. : | TEK-40H |
Product Overview : | Recombinant Human TIE2 (R915C) (771-end) fused with GST tag at N-terminal was expressed in Sf9 insect cells. |
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Species : | Human |
Source : | Insect Cells |
Tag : | GST |
Protein Length : | 771-end a.a. |
Description : | TIE2 or TEK is a receptor tyrosine kinase that is expressed principally on vascular endothelium. Disrupting TIE2 function in mice results in embryonic lethality with defects in embryonic vasculature, suggests a role in blood vessel maturation and maintenance. Angiopoietin-1 is a secreted growth factor that binds to and activates the TIE2 receptor tyrosine kinase. SHP2 and GRB2 are recruited to the activated TIE 2 kinase domain and are part of the cellular responses that mediate TIE2 function. TIE2 ex |
Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | The specific activity was determined to be 100 nmol/min/mg. |
Molecular Mass : | ~65 kDa |
Purity : | >85% by densitometry |
Applications : | Kinase Assay |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1 ug/ul |
Gene Name | TEK TEK tyrosine kinase, endothelial [ Homo sapiens ] |
Official Symbol | TEK |
Synonyms | TEK; CD202b; TIE 2; TIE2; VMCM1; hTIE2; p140 TEK; VMCM; TIE-2; CD202B; |
Gene ID | 7010 |
mRNA Refseq | NM_000459 |
Protein Refseq | NP_000450 |
MIM | 600221 |
UniProt ID | Q02763 |
Chromosome Location | 9p21 |
Pathway | Angiogenesis, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem; Rheumatoid arthritis, organism-specific biosystem; Rheumatoid arthritis, conserved biosystem; Tie2 Signaling, organism-specific biosystem; |
Function | ATP binding; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; protein tyrosine kinase activity; receptor activity; transmembrane receptor protein tyrosine kinase activity; |
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Not For Human Consumption!
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