Active Recombinant Human TEC, GST-tagged

• Cat.No.: NR4A3-1494H
• Product Overview: Full-length recombinant human TEC was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: Full length
• Description: TEC is a member of the Tec family of non-receptor protein-tyrosine kinases that are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. TEC is an integral component of T cell signaling and has a distinct role in T cell activation. Defects in TEC may be associated with myelodysplastic syndrome. TEC plays a crucial role in regulating FGF2 secretion under various physiological conditions and it inhibits CD25 expression in human T-lymphocyte.
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 10 nmol/min/mg
• Molecular Mass: ~103 kDa
• Purity: >75%
• Applications: Kinase Assay, Western Blot
• Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: NR4A3 nuclear receptor subfamily 4, group A, member 3 [ Homo sapiens ]
• Official Symbol: NR4A3
• Synonyms: NR4A3; nuclear receptor subfamily 4, group A, member 3; nuclear receptor subfamily 4 group A member 3; CHN; CSMF; MINOR; NOR1; nuclear hormone receptor NOR-1; neuron-derived orphan receptor 1; mitogen-induced nuclear orphan receptor; translocated in extraskeletal chondrosarcoma; chondrosarcoma, extraskeletal myxoid, fused to EWS; TEC
• Gene ID: 8013
• mRNA Refseq: NM_006981
• Protein Refseq: NP_008912
• MIM: 600542
• UniProt ID: Q92570
• Chromosome Location: 9q22
• Pathway: Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Hypertrophy Model, organism-specific biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem; Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem
• Function: DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; binding; metal ion binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; thyroid hormone receptor activity; zinc ion binding