NR4A3
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Official Full Name
nuclear receptor subfamily 4, group A, member 3 -
Overview
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as;a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different;versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene;and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on;chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding;Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple;transcript variants encoding different isoforms have been found for this gene. -
Synonyms
NR4A3;nuclear receptor subfamily 4, group A, member 3;nuclear receptor subfamily 4 group A member 3;CHN;CSMF;MINOR;NOR1;Chondrosarcoma, extraskeletal myxoid, fused to EWS;Mitogen induced nuclear orphan receptor;Mitogen-induced nuclear orphan receptor;Neuron derived orphan receptor 1;Neuron derived orphan receptor;Neuron-derived orphan receptor 1;NR4A3_HUMAN;Nuclear hormone receptor NOR-1;Nuclear hormone receptor NOR1;TEC;Translocated in extraskeletal chondrosarcoma;OTTHUMP00000022774;OTTHUMP00000022775;OTTHUMP00000022776;cho
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- Sf9 Cells
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- GST
- T7
- Non
- Flag
- Avi
- Fc
- DDK
- Myc
Involved Pathway
NR4A3 involved in several pathways and played different roles in them. We selected most pathways NR4A3 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR4A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | ZBTB17,CCNA1,H3F3C,CDK14,CD86,EWSR1,CD40,MEN1,IL3,DOT1L |
Protein Function
NR4A3 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR4A3 itself. We selected most functions NR4A3 had, and list some proteins which have the same functions with NR4A3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | ARNT2,AEBP2,YBX1,SFPI1,ZFP746,TFAP2A,SNAI3,SOX10,ELF1,AKNA |
| core promoter sequence-specific DNA binding | SP1,PROX1,ESR1,CREM,TP53,NFYA,SOHLH2,TRP53,NR1D2,ATF4 |
| protein homodimerization activity | ARID3A,GCH1,CASQ2,BST2,GRHPR,DNM1L,BCL2L1,TKT,FOXP3,XCL1 |
| transcription coactivator binding | TERT,ZBTB49,RORA,PASD1 |
| thyroid hormone receptor activity | NR1D2A,NR2F6,NR1D4B,NR1H4,THRA,THRB,NR1I3,NR1D4A,BRD8,THRAA |
| histone acetyltransferase binding | MTF1,PAX6,CITED2,EGR1,HIF1A,GLI3,KAT2B,TRP53,SIRT2,FOXP3 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | ETV4,TXK,MEIS1,GLI3,PAX5,PAX8,POU3F2,HOXA5,NEUROD6,NR2E1 |
| protein binding | PTPLAD1,SYNM,TDGF1,IRF4,SERPINE1,BMPR1B,NAT9,MYO10,NR1D2,WBP1 |
| steroid hormone receptor activity | VDR,THRA,RORCA,RORB,RXRGB,RORCB,RARA,RXRAB,NR5A1B,NR2C1 |
Interacting Protein
NR4A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR4A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR4A3.
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