Active Recombinant Human NTN1, Fc-tagged

• Cat.No.: NTN1-428H
• Product Overview: Human netrin-1 (aa 25-604) is fused at the C-terminus to the Fc portion of human IgG1.

Specification

• Species: Human
• Source: HEK293
• Tag: Fc
• Protein Length: 25-604 a.a.
• Description: Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin 1 is also Involved in tumorigenesis by regulating apoptosis.
• Form: Lyophilized. Contains PBS with Trehalose and Brij35.
• Bio-activity: Induces axon outgrowth.
• Molecular Mass: ~90kDa (SDS-PAGE)
• Purity: ≥95% (SDS-PAGE)
• Stability: Stable for at least 6 months after receipt when stored at -20°C.
• Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.
• Concentration: 0.1mg/ml after reconstitution.

Gene Information

• Gene Name: NTN1 netrin 1 [ Homo sapiens ]
• Official Symbol: NTN1
• Synonyms: NTN1; netrin 1; netrin-1; Netrin 1; NTN1L; netrin 1, mouse, homolog of
• Gene ID: 9423
• mRNA Refseq: NM_004822
• Protein Refseq: NP_004813
• MIM: 601614
• UniProt ID: O95631
• Chromosome Location: 17p13-p12
• Pathway: Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; DCC mediated attractive signaling, organism-specific biosystem; DSCAM interactions, organism-specific biosystem
• Function: protein binding