Recombinant Human Netrin 1, FLAG-tagged

• Cat.No.: NTN1-2173H
• Product Overview: Recombinant Human Netrin 1 (aa 28-604) is produced inHEK 293cell and fused at the N-terminus to a FLAG-tag. MW= 85kDa.

Specification

• Species: Human
• Source: HEK293
• Tag: Flag
• Protein Length: 28-604 a.a.
• Description: The Netrins (whose name means "one who guides" in Sanskrit) are a family of laminin-related secreted protein. In mice, human and rat, netrin-1, netrin-3/NTL2, netrin-4 and G-netrins have been cloned. Netrin-1 is predominantly expressed by floor plate cells as commissural axons extend toward the ventral midline. Netrin-1 induces axonal outgrowth, axon orientation and neuronal migration in neuronal development. It is chemoattractive for some neurons and chemorepellent for others.
• Concentration: 0.1mg/ml after reconstitution.
• Purity: ≥95% (SDS-PAGE).
• Formulation: Lyophilized. Contains PBS.
• Specificity: Binds to human, mouse and rat receptors UNC5H and DCC.
• Reconstitution: Reconstitute with 100µl sterile distilled water. Resuspended protein should be used immediately upon reconstitution to avoid loss in activity due to non-specific binding to the vial. Further dilutions should be made with medium containing 5% fetal calf serum or 0.5% BSA.
• Storage And Stability: Stable for at least 6 months after receipt when stored at -20°C. Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.

Gene Information

• Gene Name: NTN1 netrin 1 [ Homo sapiens ]
• Synonyms: NTN1; netrin 1; NTN1L; Netrin-1; netrin 1, mouse, homolog of
• Gene ID: 9423
• mRNA Refseq: NM_004822
• Protein Refseq: NP_004813
• MIM: 601614
• UniProt ID: O95631
• Chromosome Location: 17p13-p12
• Pathway: Axon guidance
• Function: protein binding