Active Recombinant Human NCOR1, His-tagged

• Cat.No.: NCOR1-8484H
• Product Overview: Recombinant Human NCOR1, fused with His tag, was expressed in Sf21 Cells.

Specification

• Description: This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.
• Source: Sf21 Cells
• Species: Human
• Tag: His
• Form: 20 mM Tris-Cl, pH 7.9, 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA
• Bio-activity: 1 unit equals 1 ng of purified protein. 100 units are sufficient for a protein-protein interaction assay.
• Purity: >95% as determined by SDS-PAGE
• Storage: -80 °C
• Concentration: 700 μg/ml
• Shipping: Dry Ice

Gene Information

• Gene Name: NCOR1 nuclear receptor corepressor 1 [ Homo sapiens ]
• Official Symbol: NCOR1
• Synonyms: NCOR1; nuclear receptor corepressor 1; nuclear receptor co repressor 1; hCIT529I10; hN CoR; KIAA1047; MGC104216; N CoR; thyroid hormone and retinoic acid receptor associated corepressor 1; TRAC1; nuclear receptor co-repressor 1; thyroid hormone- and retinoic acid receptor-associated corepressor 1; N-CoR; N-CoR1; hN-CoR
• Gene ID: 9611
• mRNA Refseq: NM_006311
• Protein Refseq: NP_006302
• MIM: 600849
• UniProt ID: O75376
• Chromosome Location: 17p11.2
• Pathway: Adipogenesis, organism-specific biosystem; BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Circadian Repression of Expression by REV-ERBA, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Developmental Biology, organism-specific biosystem
• Function: histone deacetylase binding; histone deacetylase regulator activity; protein binding; retinoid X receptor binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; thyroid hormone receptor binding; transcription corepressor activity; transcription corepressor activity; transcription regulatory region DNA binding