NCOR1
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Official Full Name
nuclear receptor corepressor 1 -
Overview
The most well characterized nuclear receptor corepressors are SMRT (silencing mediator for retinoic acid and thyroid hormone receptors) and its close paralog NCoR1 (nuclear receptor corepressor). NCoR1 functions to transcriptionally silence various unliga -
Synonyms
NCOR1;nuclear receptor corepressor 1;nuclear receptor co repressor 1;hCIT529I10;hN CoR;KIAA1047;MGC104216;N CoR;thyroid hormone and retinoic acid receptor associated corepressor 1;TRAC1;nuclear receptor co-repressor 1;thyroid hormone- and reti
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NCOR1-8484H |
Active Recombinant Human NCOR1, His-tagged
|
Sf21 Insect Cell | Human | His |
|
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| NCOR1-10610Z | Recombinant Zebrafish NCOR1 | Mammalian Cell | Zebrafish | His |
|
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| NCOR1-16H | Active Recombinant Human NCOR1/HDAC3 Protein, GST-tagged | Insect Cell | Human | GST | NCOR1 amino acids 397-503 |
|
| NCOR1-28430TH | Recombinant Human NCOR1, FLAG-tagged | Human | Flag | Full L. 1-2440 a.a. |
|
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| NCOR1-1705H | Recombinant Human NCOR1 protein, His & T7-tagged | E.coli | Human | His&T7 | Met1~Val284 |
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| Ncor1-1706M | Recombinant Mouse Ncor1 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Met1~Val285 |
|
Involved Pathway
NCOR1 involved in several pathways and played different roles in them. We selected most pathways NCOR1 participated on our site, such as Thyroid hormone signaling pathway,Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCOR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone signaling pathway | PLCG1,NOTCH3,PIK3CD,MED4,PLCB2,PLN,THRB,PRKACA,KAT2A,PFKP |
| Transcriptional misregulation in cancer | PAX5,BCL2A1,NGFR,CCND2,SSX2,MLF1,BCL6,PLAU,PAX3,PAX8 |
Protein Function
NCOR1 has several biochemical functions, for example, RNA polymerase II activating transcription factor binding,histone deacetylase binding,histone deacetylase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NCOR1 itself. We selected most functions NCOR1 had, and list some proteins which have the same functions with NCOR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II activating transcription factor binding | T,POU1F1,EOMES,TBX6,HIPK2,HNF4A,BHLHE40,TBX3,ZFPM1,EGR2 |
| ligand-dependent nuclear receptor binding | C1D,PPARGC1A,SRA1,NCOA2,ISL1,NCOA1,BAZ2A,TRIP4,TADA3,MED1 |
| sequence-specific DNA binding | POU2F3,ZSCAN12,HOXD11A,CALCOCO1,ZNF165,PRRXL1,HOXB10A,HOXC8,TFAP2B,RXRGA |
| histone deacetylase regulator activity | TP53,TRP53,MAPK8 |
| thyroid hormone receptor binding | NR0B2,HMGN3,MED24,MED12,THRAP3,MED1,MED13,TRIP6,NSD1,MED4 |
| retinoid X receptor binding | NR1H4,PPARG,VDR,FUS,NR4A2,NCOA1,NSD1,MED25,NR0B2,NR1H2 |
| transcription factor activity, sequence-specific DNA binding | POU4F1,PPARAA,GTF2H4,ZIM3,GATAD2A,NR2F6B,CTNNB1,ONECUT3,KAT7A,TFAM |
| protein binding | BABAM1,BAK1,TWF2,CLOCKB,TNNI2,SLC22A3,MOB1A,TPP2,MSH6,UBE2G2 |
| transcription corepressor activity | ZEB1,HDAC3,ZNF593,ASXL1,ENO1,CDX2,TRIM28,RYBP,ZHX2,SKIL |
Interacting Protein
NCOR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCOR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCOR1.
HDAC3;RARA;SKI;TRIM28;SMARCA4;SMARCB1;DHX30
NCOR1 Related Signal Pathway
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