Active Recombinant Human NCOA1, Receptor Interacting Domain, Non-tagged

• Cat.No.: NCOA1-1161H

Specification

• Cat. No.: NCOA1-1161H
• Description: Steroid receptor coactivator 1 (SRC1) is a transcriptional coactivator that mediates the activating functions of many of the nuclear hormone receptors. It is also known as NCoA1 and is a member of the SRC/p160 coactivator family. SRC1 has been shown to be over expressed in some cancers. SRC1 is a 160 kDa protein that contains several LXXLL motifs, which are involved in nuclear receptor interaction. The region 627-786 contains 3 LXXLL motifs that are involved in interaction with nuclear hormone receptors and has been previously used in assays detecting liganddependent receptor-cofactor interactions. This protein does not contain any tag and will be useful for assays where a native untagged protein is desired.
• Source: E. coli.
• Form: Liquid. Supplied in 20 mM Tris-HCl pH 8.0, 20% glycerol, 100 mM KCl, 0.2 mM EDTA and 1 mM DTT.
• Purity: > 95% by SDS-PAGE.
• Activity: 100 ng are sufficient for a protein-protein interaction assay.
• Application: Recombinant SCR1 (627-786) can be used for proteinprotein interaction assays.
• Usage: For in vitro use only.
• Storage: Quality guaranteed for 12 months store at -80°C. Avoid freeze / thaw cycles.
• Tag: Non

Gene Information

• Gene Name: NCOA1 nuclear receptor coactivator 1 [ Homo sapiens ]
• Synonyms: NCOA1; nuclear receptor coactivator 1; SRC1; KAT13A; RIP160; F-SRC-1; bHLHe42; bHLHe74; MGC129719; MGC129720; Hin-2 protein; OTTHUMP00000155181; OTTHUMP00000155182; PAX3/NCOA1 fusion protein; steroid receptor coactivator-1; EC 2.3.1.48; OTTHUMP00000155183; NCoA-1; RIP160; SRC-1; Protein Hin-2; Renal carcinoma antigen NY-REN-52; Steroid receptor coactivator 1; nuclear receptor coactivator 1
• Gene ID: 8648
• mRNA Refseq: NM_003743
• Protein Refseq: NP_003734
• MIM: 602691
• UniProt ID: Q15788
• Chromosome Location: 2p23
• Function: DNA binding; acyltransferase activity; androgen receptor binding; chromatin binding; histone acetyltransferase activity; nuclear hormone receptor binding; protein N-terminus binding; signal transducer activity; transcription coactivator activity; transcription regulator activity; transferase activity