NCOA1
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Official Full Name
nuclear receptor coactivator 1 -
Overview
There are three members of the steroid receptor co-activator (SRC) family of proteins: SRC-1 (NCoA-1), SRC-2 (TIF2/GRIP1/NCoA-2), and SRC-3 (ACTR/pCIP/RAC3/TRAM-1/AIB1). All SRC family members share significant structural homology and function to stimulat -
Synonyms
NCOA1;nuclear receptor coactivator 1;bHLHe74;F SRC 1;KAT13A;NCoA 1;RIP160;SRC1;Hin-2 protein;PAX3/NCOA1 fusion protein;steroid receptor coactivator-1;renal carcinoma antigen NY-REN-52;class E basic helix-loop-helix protein 74;F-SRC-1;bHLHe42
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- Non
- GST
- His
- Flag
- Avi
- Fc
Involved Pathway
NCOA1 involved in several pathways and played different roles in them. We selected most pathways NCOA1 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCOA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone signaling pathway | EP300,GATA4,KAT2B,MAP2K1,HDAC1,MAPK1,PIK3CB,NOTCH1,TP53,MAPK3 |
Protein Function
NCOA1 has several biochemical functions, for example, RNA polymerase II regulatory region DNA binding,RNA polymerase II transcription coactivator activity,androgen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCOA1 itself. We selected most functions NCOA1 had, and list some proteins which have the same functions with NCOA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| androgen receptor binding | PRKCB,KDM4C,RNF14,RAN,PIAS1,PKN1,RB1,KDM1A,KAT5,TGFB1I1 |
| RNA polymerase II transcription coactivator activity | TBX20,SOX4,MKL1B,CITED1,POU3F1,POU1F1,SMARCA4,RERE,ANKRD1,SOX11 |
| histone acetyltransferase activity | KAT7A,CREBBP,MED24,KAT7B,KAT5,EP300,KAT8,METTL8,MGEA5,HAT1 |
| transcription coactivator activity | ING4,PPARGC1A,NR2C2,MED20,HAND1,CARM1,GATA3,PSMD9,RBPMS,MAML2 |
| retinoid X receptor binding | RARG,PPARG,NRIP1,RARB,FUS,NR0B2,HMGA1-RS1,NSD1,HMGA1,NCOR1 |
| nuclear hormone receptor binding | SNW1,TACC2,Ankar,MYOD1,NRIP1,BUD31,NCOA2,HIF1A,CTNNB1,SIRT1 |
| protein N-terminus binding | SERPINB1A,ID1,SCT,GLRX,UNC13A,KCNQ2,CSNK2A2,EXOC4,VPS25,PHB2 |
| ligand-dependent nuclear receptor binding | PPARGC1A,NR1H4,NCOA2,UBA3,C1D,TADA3,NCOA3,MED1,BAZ2A,NCOR1 |
| chromatin binding | SMAD2,MCM5,TLE1,ZEB1,ZFP354B,HMGB3B,RAD51,HMGB1,FOXO1,KLHDC3 |
Interacting Protein
NCOA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCOA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCOA1.
ESR1;RARA;RXRA;CREBBP
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