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Active Recombinant Human IFNB1 Protein (Met22-Asn187), C-His tagged, Animal-free, Carrier-free

Cat.No. : IFNB1-155H
Product Overview : Recombinant Human IFNB1 Protein (Met22-Asn187) with C-His tag was expressed in E. coli and Animal-free as well as Carrier-free.
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Description : Interferon-Beta 1a (IFN-beta 1a) is a leukocyte interferon, which is a variant of Interferon-beta. IFN-beta 1a is a 19 kDa protein containing 166 amino acid residues. It could bind the interferon receptors that activates the signal transduction of immune responses through the Jak/STAT pathway in leukocytes and lymphoblastoid cells.
Source : E. coli
Species : Human
Tag : His
Form : Lyophilized
Bio-activity : Measure by its ability to induce apoptosis in HeLa cells. The ED50 for this effect is < 15 ng/mL. Measure by its ability to induce cytotoxicity in TF-1 cells. The ED50 for this effect is < 0.1 ng/mL. The specific activity of recombinant human IFN beta 1a is approximately >1 × 10⁷ IU/ mg.
Molecular Mass : The protein has a calculated MW of 20.84 kDa.
The protein migrates as 15 kDa under reducing condition (SDS-PAGE analysis).
Protein length : Met22-Asn187
Endotoxin : < 0.1 EU/μg of the protein by the LAL method.
Purity : >98% as determined by SDS-PAGE analysis.
Storage : This product is stable after storage at:
-20 centigrade for 12 months in lyophilized state from date of receipt.
-20 or -80 centigrade for 1 month under sterile conditions after reconstitution.
Avoid repeated freeze/thaw cycles.
Storage Buffer : Lyophilized from a 0.2 μm filtered solution of PBS, pH 8.0.
Reconstitution : It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
Shipping : The product is shipped with polar packs. Upon receipt, store it immediately at -20 centigrade or lower for long term storage.
Gene Name : IFNB1 interferon, beta 1, fibroblast [ Homo sapiens (human) ]
Official Symbol : IFNB1
Synonyms : IFNB1; interferon, beta 1, fibroblast; IFNB; interferon beta; IFB; IFF; IFN-beta; fibroblast interferon; MGC96956;
Gene ID : 3456
mRNA Refseq : NM_002176
Protein Refseq : NP_002167
MIM : 147640
UniProt ID : P01574

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
06/24/2021

    The manufacturer not only ensures the provision of superior protein but also aids researchers with their solid technical support, offering the necessary resources to optimize experimental protocols.

    08/29/2020

      the IFNB1 protein offers numerous advantages for researchers conducting trials due to its high quality and stability.

      11/08/2018

        manufacturers or suppliers of proteins can play a crucial role in supporting researchers during trials.

        Q&As (5)

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        Are there any contraindications for IFNB1 treatment? 01/26/2021

        IFNB1 is generally not recommended for individuals with a history of hypersensitivity to interferons or other components of the drug. It should be used with caution in patients with certain pre-existing medical conditions.

        Can IFNB1 be used in cancer treatment? 02/11/2020

        IFNB1 is being investigated for its potential role in cancer treatment due to its immunomodulatory effects. Clinical trials are ongoing to evaluate its efficacy in various types of cancer.

        What are the potential side effects of IFNB1 treatment? 06/27/2019

        Common side effects include flu-like symptoms, injection site reactions, and changes in blood cell counts. Serious side effects are rare but can include liver problems and allergic reactions.

        How is IFNB1 administered in clinical settings? 06/04/2019

        IFNB1 is often administered through subcutaneous or intramuscular injections. The frequency and dosage depend on the specific condition being treated.

        In what other conditions is IFNB1 protein clinically utilized? 10/09/2016

        IFNB1 is also used in the treatment of certain viral infections, such as hepatitis B and C. It has antiviral properties that can inhibit viral replication.

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