Active Recombinant Human IFNB1

• Cat.No.: IFNB1-99H
• Product Overview: Human IFNB1 (P01574, 22 a.a.-187 a.a.) partial recombinant protein expressed in CHO cells.

Specification

• Cat. No.: IFNB1-99H
• Description: Interferon beta is a protein that in humans is encoded by the IFNB1 gene.
• Sequence: MSYNLLGFL QRSSNFQCQK LLWQLNGRLE YCLKDRMNFD IPEEIKQLQQ FQKEDAALTI YEMLQNIFAI FRQDSSSTGW NETIVENLLA NVYHQINHLK TVLEEKLEKE DFTRGKLMSS LHLKRYYGRI LHYLKAKEYS HCAWTIVRVE ILRNFYFINR LTGYLRN
• Theoretical MW (kDa): 19
• Form: Lyophilized
• Preparation Method: Mammalian cell (CHO) expression system
• Purity: > 98% by SDS-PAGE and HPLC
• Endotoxin Level: < 0.1 ng/ug (1 EU/ug)
• Activity: The activity was determined by the viral resistance assay of Human WISH cells was found to be in the range of 3 x 10⁸ IU/mg.
• Application: SDS-PAGE
• Storage Buffer: Lyophilized from sodium acetate solution pH 4.8
• Storage: Store at -20°C on dry atmosphere for 2 years. After reconstitution with deionized water, store at 4°C for 1 month or store at -20°C for 6 months. Aliquot to avoid repeated freezing and thawing.
• Unitprot ID: P01574
• Pathways: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Natural killer cell mediated cytotoxicity; RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway
• Tag: Non

Gene Information

• Gene Name: IFNB1 interferon, beta 1, fibroblast [ Homo sapiens ]
• Official Symbol: IFNB1
• Synonyms: IFNB1; Interferon, beta 1, fibroblast; IFB; IFF; IFNB; MGC96956; Interferon beta; Leukocyte interferon; B cell interferon; Type I interferon; IFNB1; IFN-b 1a; IFN-beta; OTTHUMP00000021131; Fibroblast interferon
• Gene ID: 3456
• mRNA Refseq: NM_002176
• Protein Refseq: NP_002167
• MIM: 147640
• Chromosome Location: 9p21
• Function: cytokine activity; interferon-alpha/beta receptor binding; transcription corepressor activity

Reviews

06/24/2021

The manufacturer not only ensures the provision of superior protein but also aids researchers with their solid technical support, offering the necessary resources to optimize experimental protocols.

08/29/2020

the IFNB1 protein offers numerous advantages for researchers conducting trials due to its high quality and stability.

11/08/2018

manufacturers or suppliers of proteins can play a crucial role in supporting researchers during trials.

Q&As

Are there any contraindications for IFNB1 treatment?

IFNB1 is generally not recommended for individuals with a history of hypersensitivity to interferons or other components of the drug. It should be used with caution in patients with certain pre-existing medical conditions.

Can IFNB1 be used in cancer treatment?

IFNB1 is being investigated for its potential role in cancer treatment due to its immunomodulatory effects. Clinical trials are ongoing to evaluate its efficacy in various types of cancer.

What are the potential side effects of IFNB1 treatment?

Common side effects include flu-like symptoms, injection site reactions, and changes in blood cell counts. Serious side effects are rare but can include liver problems and allergic reactions.

How is IFNB1 administered in clinical settings?

IFNB1 is often administered through subcutaneous or intramuscular injections. The frequency and dosage depend on the specific condition being treated.

In what other conditions is IFNB1 protein clinically utilized?

IFNB1 is also used in the treatment of certain viral infections, such as hepatitis B and C. It has antiviral properties that can inhibit viral replication.