Active Recombinant Human HLA-DRB1, Fc-tagged

• Cat.No.: HLA-DRB1-713H
• Product Overview: The recombinant human VNN2-Fc fusion is expressed as a 697 amino acid protein consisting of Gln23 - Ser492 region of VNN2 (Uniprot Accession #O95498) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.

Specification

• Source: Human cells
• Species: Human
• Tag: Fc
• Form: Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free).
• Bio-activity: VNN2 hydrolyzes D-pantetheine and releases cysteamine.
• Molecular Mass: Calculated molecular mass (kDa): 78.7; Estimated by SDS-PAGE under reducing condition (kDa): 80-85
• Endotoxin: <0.1 eu="" per="" 1="" μg="" of="" purified="" recombinant="" protein="" determined="" by="" the="" lal="">
• Purity: >95% judged by SDS-PAGE under reducing condition.
• Storage: The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.
• Protein length: 23-492 a.a.

Gene Information

• Gene Name: HLA-DRB1 major histocompatibility complex, class II, DR beta 1 [ Homo sapiens ]
• Official Symbol: HLA-DRB1
• Synonyms: HLA-DRB1; major histocompatibility complex, class II, DR beta 1; HLA DR1B; DW2.2/DR2.2; MHC class II antigen; lymphocyte antigen DRB1; MHC class II HLA-DRw10-beta; human leucocyte antigen DRB1; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein; HLA class II histocompatibility antigen, DR-1 beta chain; SS1; DRB1; DRw10; HLA-DRB; HLA-DR1B; FLJ75017; FLJ76359
• Gene ID: 3123
• mRNA Refseq: NM_001243965
• Protein Refseq: NP_001230894
• MIM: 142857
• UniProt ID: P01911
• Chromosome Location: 6p21.3
• Pathway: Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem
• Function: MHC class II receptor activity; MHC class II receptor activity