Active Recombinant Human GDF7 Protein

• Cat.No.: GDF7-051H
• Product Overview: The mature recombinant human GDF-7 protein (322-450aa) without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Protein Length: 322-450 a.a.
• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma.
• Bio-activity: Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is typically 0.25-1.25 μg/mL.
• Molecular Mass: 14 kDa
• Product-Related Proteins: 322-450
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: GDF7 growth differentiation factor 7 [ Homo sapiens (human) ]
• Official Symbol: GDF7
• Synonyms: GDF7; growth differentiation factor 7; BMP12; growth/differentiation factor 7; Names; GDF-7
• Gene ID: 151449
• mRNA Refseq: NM_182828
• Protein Refseq: NP_878248
• MIM: 604651
• UniProt ID: Q7Z4P5