Active Recombinant Human FCGRT and B2M Complex Protein, C-His-tagged

• Cat.No.: FCGRT-B2M-23H
• Product Overview: Recombinant Human FCGRT&B2M Complex Protein, fused to His-tag, was expressed in HEK293T.

Specification

• Species: Human
• Source: HEK293
• Tag: His
• Protein Length: FCGRT, 280aa; B2M, 99aa
• Description: This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants.
  This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.
• Form: Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol.
• Bio-activity: Measured by its binding ability in a functional ELISA with Human IgG1 Fc.
• Molecular Mass: 31.1kDa(FCGRT), 11.7kDa(B2M)
• AA Sequence: FCGRT
  AESHLSLLYH LTAVSSPAPG TPAFWVSGWL GPQQYLSYNS LRGEAEPCGA WVWENQVSWY WEKETTDLRI KEKLFLEAFK ALGGKGPYTL QGLLGCELGP DNTSVPTAKF ALNGEEFMNF DLKQGTWGGD WPEALAISQR WQQQDKAANK ELTFLLFSCP HRLREHLERG RGNLEWKEPP SMRLKARPSS PGFSVLTCSA FSFYPPELQL RFLRNGLAAG TGQGDFGPNS DGSFHASSSL TVKSGDEHHY CCIVQHAGLA QPLRVELESP AKSS
  B2M
  IQRTPKIQVY SRHPAENGKS NFLNCYVSGF HPSDIEVDLL KNGERIEKVE HSDLSFSKDW SFYLLYYTEF TPTEKDEYAC RVNHVTLSQP KIVKWDRDM
• N-terminal Sequence Analysis: 24-297aa(FCGRT), 21-119aa(B2M)
• Endotoxin: < 1 EU per 1ug of protein (determined by LAL method).
• Purity: > 95% by SDS-PAGE
• Applications: SDS-PAGE, Bioactivity
• Usage: For research use only. This product is not intended or approved for human, diagnostics or veterinary use.
• Storage: Can be stored at 2 centigrade to 8 centigrade for 1 week. For long term storage, aliquot and store at -20 centigrade to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25mg/ml (determined by Absorbance at 280nm).

Gene Information

• Gene Name: FCGRT Fc gamma receptor and transporter [ Homo sapiens (human) ]&B2M beta-2-microglobulin [ Homo sapiens (human) ]
• Official Symbol: FCGRT&B2M
• Synonyms: IgG receptor FcRn; Neonatal Fc receptor; FCRN
• Gene ID: 2217&567
• mRNA Refseq: NM_004107.5&NM_004048.4
• Protein Refseq: NP_004098.1&NP_004039.1
• MIM: 601437&109700
• UniProt ID: P55899&P61769