Active Recombinant Human ARHGAP1 Protein (Full Length), N-His tagged

• Cat.No.: ARHGAP1-37H
• Product Overview: Active Recombinant full-length human RhoGAP was expressed in E. coli cells using an N-terminal His tag.

Specification

• Description: RhoGAP is responsible for inactivating Rho GTPases by accelerating the hydrolysis of GTP to GDP. This enzymatic activity promotes the conversion of Rho GTPases from an active, GTP-bound state to an inactive, GDP-bound state, thereby regulating downstream signaling pathways. The inactivation of Rho GTPases is crucial for maintaining cellular homeostasis and controlling processes such as cell shape changes, cell adhesion dynamics and cell motility. Dysregulation of RhoGAP activity has been implicated in various human diseases, including cancer, cardiovascular diseases, and neurological disorders.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: Observed MW: ~55 kDa
  Calculated MW: ~50 kDa
• Protein length: Full Length
• Purity: > 90%
• Stability: One year at –70 centigrade from date of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μL
• Storage Buffer: Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.25mM DTT, 25% glycerol.
• Shipping: Dry ice

Gene Information

• Gene Name: ARHGAP1 Rho GTPase activating protein 1 [ Homo sapiens (human) ]
• Official Symbol: ARHGAP1
• Synonyms: ARHGAP1; Rho GTPase activating protein 1; rho GTPase-activating protein 1; Cdc42GAP; CDC42GAP; p50rhoGAP; RhoGAP; p50-RhoGAP; CDC42 GTPase-activating protein; GTPase-activating protein rhoOGAP; rho-type GTPase-activating protein 1; rho-related small GTPase protein activator; RHOGAP; RHOGAP1
• Gene ID: 392
• mRNA Refseq: NM_004308
• Protein Refseq: NP_004299
• MIM: 602732
• UniProt ID: Q07960