Active Recombinant Full Length Human RAD18 Protein

• Cat.No.: RAD18-421HF
• Product Overview: Recombinant full length Human RAD18 (aa 1-495) with a proprietary tag; 83.2 kDa inclusive of tag.

Specification

• Description: The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif.Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.
• Source: In Vitro Cell Free System
• Species: Human
• Form: Liquid
• Bio-activity: Useful for Antibody Production and Protein Array
• Molecular Mass: 83.200kDa inclusive of tags
• Protein length: 495 amino acids
• Purity: Proprietary Purification
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles.
• Storage Buffer: pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione.

Gene Information

• Gene Name: RAD18 RAD18 homolog (S. cerevisiae) [ Homo sapiens ]
• Official Symbol: RAD18
• Synonyms: RAD18; RAD18 homolog (S. cerevisiae); E3 ubiquitin-protein ligase RAD18; RNF73
• Gene ID: 56852
• mRNA Refseq: NM_020165
• Protein Refseq: NP_064550
• MIM: 605256
• UniProt ID: Q9NS91